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Loperamide
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===Children=== The use of loperamide in children under two years is not recommended. Rare reports of fatal [[paralytic ileus]] associated with [[abdominal distention]] have been made. Most of these reports occurred in the setting of acute [[dysentery]], overdose, and with very young children less than two years of age.<ref>{{ cite web | url = http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6651 | title = Imodium (Loperamide Hydrochloride) Capsule | work = DailyMed | publisher = NIH | url-status = live | archive-url = https://web.archive.org/web/20100413032222/http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=6651 | archive-date = 13 April 2010 | df = dmy-all }}</ref> A review of loperamide in children under 12 years old found that serious adverse events occurred only in children under three years old. The study reported that the use of loperamide should be contraindicated in children who are under 3, systemically ill, malnourished, moderately dehydrated, or have bloody diarrhea.<ref>{{cite journal | vauthors=Li ST, Grossman DC, Cummings P | title = Loperamide therapy for acute diarrhea in children: systematic and meta-analysis | journal = PLOS Medicine | volume = 4 | issue = 3 | date = 2007 | pages = e98 | pmid=17388664 | doi=10.1371/journal.pmed.0040098 | pmc=1831735 | doi-access = free }}</ref> In 1990, all formulations for children of the antidiarrheal loperamide were banned in Pakistan.<ref>{{ cite web|url=http://www.essentialdrugs.org/edrug/archive/199708/msg00056.php |title=E-DRUG: Chlormezanone |publisher=Essentialdrugs.org |url-status=dead |archive-url=https://web.archive.org/web/20110726035911/http://www.essentialdrugs.org/edrug/archive/199708/msg00056.php |archive-date=26 July 2011 }}</ref> The [[National Health Service]] in the United Kingdom recommends that loperamide should only be given to children under the age of twelve if prescribed by a doctor. Formulations for children are only available on prescription in the UK.<ref>{{cite web |date=20 December 2018 |title=Loperamide: a medicine used to treat diarrhoea |url=https://www.nhs.uk/medicines/loperamide/ |access-date=7 October 2023 |website=[[National Health Service]] }}</ref>
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