Editing MPTP (section)

==Synthesis and uses==
MPTP was first synthesized as a potential [[analgesic]] in 1947 by Ziering ''et al.'' by reaction of [[phenylmagnesium bromide]] with [[1-methyl-4-piperidinone]].<ref>{{cite journal | journal = Journal of Organic Chemistry | year = 1947 | volume = 12 | issue = 6 | pages = 885–893 | title = Piperidine Derivatives. Part II. 2-Phenyl- and 2-Phenylalkyl-Piperidines |author1=Lee, J. |author2=Ziering, A. |author3=Heineman, S. D. |author4=Berger, L. | doi = 10.1021/jo01170a021 | pmid = 18919741 }}</ref> It was tested as a treatment for various conditions, but the tests were halted when Parkinson-like symptoms were noticed in monkeys. In one test of the substance, two of six human subjects died.<ref name="vinken">{{cite book |author1=Vinken, P. J. |author2=Bruyn, G. W. | title = Intoxications of the Nervous System | page = 369 | publisher = Elsevier Health Sciences | year = 1994 | isbn = 978-0-444-81284-1}}</ref>

MPTP is used in industry as a chemical intermediate; the [[chloride]] of the toxic metabolite MPP<sup>+</sup>, [[cyperquat]], has been used as a [[herbicide]].<ref name="vinken" /> While cyperquat is not used anymore, the closely related substance [[paraquat]] is still being used as a herbicide in some countries.