Editing Management of HIV/AIDS (section)

===Non-nucleoside reverse-transcriptase inhibitors===
[[Reverse-transcriptase inhibitor|Non-nucleoside reverse-transcriptase inhibitors (NNRTI)]] inhibit reverse transcriptase by binding to an [[Allosteric regulation|allosteric site]] of the enzyme; NNRTIs act as [[Non-competitive inhibition|non-competitive inhibitors]] of [[reverse transcriptase]]. NNRTIs affect the handling of substrate (nucleotides) by reverse transcriptase by binding near the active site. NNRTIs can be further classified into 1st generation and 2nd generation NNRTIs. 1st generation NNRTIs include [[nevirapine]] and [[efavirenz]]. 2nd generation NNRTIs are [[etravirine]] and [[rilpivirine]].<ref name="Kalyan Das 2013 111-118"/> [[Subtypes of HIV#HIV-2|HIV-2]] is intrinsically resistant to NNRTIs.<ref name=":13" />