Editing Microsome (section)

== MTP ==

Iqbal, Jahangir, and Al-Qarni studied the [[microsomal triglyceride transfer protein]] (MTP). MTP is an endoplasmic reticulum resident protein and assists in transferring neutral lipids to nascent [[apolipoprotein B]]. MTP has a large use for abetalipoproteinemia patients with MTP mutations because of how it affects the assembly and secretion of apoB-containing [[lipoprotein]]s. These MTP mutations are linked with not having circulation of the apoB-containing lipoproteins. MTP is also involved with cholesterol ester and cluster of differentiation 1d biosynthesis. Transferring [[sphingolipid]]s to apoB-containing lipoproteins also falls under the ability of MTP. MTP works with the [[homeostasis]] of [[lipid]]s and lipoproteins and is related to certain pathophysiological conditions and [[metabolic diseases]].<ref>Iqbal, J., Jahangir, Z., & Al-Qarni , A. A. (2020). Microsomal triglyceride transfer protein: From lipid metabolism to metabolic diseases. Advances in experimental medicine and biology. Retrieved November 29, 2022, from {{PMID|32705593}}</ref>

Wang et al. explored [[drug metabolism]] in vitro using human liver microsomes and human liver S9 fractions. The study found significant differences between human liver microsomes and human liver S9 fractions in drug-metabolizing enzyme and transporter protein concentrations.  The protein-protein correlations of these drug-metabolizing enzymes and transporters was determined relating to the two hepatic preparations.<ref>Wang, X. et al. (2020, January). Comparative proteomics analysis of human liver microsomes and S9 fractions. Drug metabolism and disposition: the biological fate of chemicals. Retrieved November 29, 2022, from {{PMID|31699809}}</ref>