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Muscle relaxant
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===Terminology=== Because they may act at the level of the cortex, brain stem, or spinal cord, or all three areas, they have traditionally been referred to as "centrally acting" muscle relaxants. However, it is now known not every agent in this class has CNS activity (e.g., [[dantrolene]]), so this name is inaccurate.<ref name=" MillerRD"/> Most sources still use the term "centrally acting muscle relaxant". According to [[Medical Subject Headings|MeSH]], dantrolene is usually classified as a centrally acting muscle relaxant.<ref>{{MeshName|Dantrolene}}</ref> The [[World Health Organization]], in its [[Anatomical Therapeutic Chemical Classification System|ATC]], uses the term "centrally acting agents",<ref>{{cite web |url=http://www.whocc.no/atc_ddd_index/?code=M03B |title=M03B Muscle Relaxants, Centrally acting agents |work=ATC/DDD Index |publisher=WHO Collaborating Centre for Drug Statistics Methodology }}</ref> but adds a distinct category of "directly acting agents", for dantrolene.<ref>{{cite web |url=http://www.whocc.no/atc_ddd_index/?code=M03CA01 |title=M03CA01 Dantrolene |work=ATC/DDD Index |publisher=WHO Collaborating Centre for Drug Statistics Methodology }}</ref> Use of this terminology dates back to at least 1973.<ref name="pmid4712630">{{cite journal |vauthors=Ellis KO, Castellion AW, Honkomp LJ, Wessels FL, Carpenter JE, Halliday RP |title=Dantrolene, a direct acting skeletal muscle relaxant |journal=J Pharm Sci |volume=62 |issue=6 |pages=948β51 |date=June 1973 |pmid=4712630 |doi=10.1002/jps.2600620619 }}</ref> The term "spasmolytic" is also considered a synonym for [[antispasmodic]].<ref name="urlDorlands Medical Dictionary:antispasmodic">{{cite web |url=http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=/ppdocs/us/common/dorlands/dorland/one/000006336.htm#000006336 |title=Dorlands Medical Dictionary:antispasmodic |archive-url=https://web.archive.org/web/20091001022542/http://www.mercksource.com/pp/us/cns/cns_hl_dorlands_split.jsp?pg=%2Fppdocs%2Fus%2Fcommon%2Fdorlands%2Fdorland%2Fone%2F000006336.htm#000006336 |archive-date=2009-10-01 |url-status=dead }}</ref>
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