Editing Mutation (section)

=== Error-prone replication bypass ===

There is increasing evidence that the majority of spontaneously arising mutations are due to error-prone replication ([[translesion synthesis]]) past DNA damage in the template strand. In [[mouse|mice]], the majority of mutations are caused by translesion synthesis.<ref>{{cite journal | vauthors = Stuart GR, Oda Y, de Boer JG, Glickman BW | title = Mutation frequency and specificity with age in liver, bladder and brain of lacI transgenic mice | journal = Genetics | volume = 154 | issue = 3 | pages = 1291–300 | date = March 2000 | doi = 10.1093/genetics/154.3.1291 | pmid = 10757770 | pmc = 1460990 }}</ref> Likewise, in [[yeast]], Kunz et al.<ref>{{cite journal | vauthors = Kunz BA, Ramachandran K, Vonarx EJ | title = DNA sequence analysis of spontaneous mutagenesis in Saccharomyces cerevisiae | journal = Genetics | volume = 148 | issue = 4 | pages = 1491–505 | date = April 1998 | doi = 10.1093/genetics/148.4.1491 | pmid = 9560369 | pmc = 1460101 }}</ref> found that more than 60% of the spontaneous single base pair substitutions and deletions were caused by translesion synthesis.