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Myenteric plexus
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====Receptors==== Since many of the same neurotransmitters are found in the ENS as the brain, it follows that myenteric neurons can express receptors for both peptide and non-peptide (amines, amino acids, purines) neurotransmitters. Generally, expression of a receptor is limited to a subset of myenteric neurons, with probably the only exception being expression of nicotinic cholinergic receptors on all myenteric neurons. One receptor that has been targeted for therapeutic reasons has been the [[5-HT4 receptor|5-hydroxytryptamine (5-HT<sub>4</sub>) receptor]]. Activating this pre-synaptic receptor enhances cholinergic neurotransmission and can stimulate gastrointestinal motility.<ref>{{cite journal |doi=10.1152/ajpgi.00496.2009 |pmid=20413719 |pmc=2904117 |title=Critical role of 5-HT1A, 5-HT3, and 5-HT7 receptor subtypes in the initiation, generation, and propagation of the murine colonic migrating motor complex |journal=AJP: Gastrointestinal and Liver Physiology |volume=299 |issue=1 |pages=G144β57 |year=2010 |last1=Dickson |first1=E. J. |last2=Heredia |first2=D. J. |last3=Smith |first3=T. K. }}</ref> The enteric nervous system exhibits taste receptors similar to the ones in the tongue. The taste receptor [[TAS1R3]] and the taste G protein [[gustducin]] are two of the most common. These receptors sense "sweetness" on the tongue and sense glucose in the enteric nervous system. These receptors help regulate the secretion of insulin and other hormones that are responsible for controlling blood sugar levels.<ref>{{cite journal |doi=10.1073/pnas.0706678104 |pmid=17724332 |pmc=1986615 |jstor=25449086 |title=T1R3 and gustducin in gut sense sugars to regulate expression of Na<sup>+</sup>-glucose cotransporter 1 |journal=Proceedings of the National Academy of Sciences |volume=104 |issue=38 |pages=15075β80 |year=2007 |last1=Margolskee |first1=Robert F. |last2=Dyer |first2=Jane |last3=Kokrashvili |first3=Zaza |last4=Salmon |first4=Kieron S. H. |last5=Ilegems |first5=Erwin |last6=Daly |first6=Kristian |last7=Maillet |first7=Emeline L. |last8=Ninomiya |first8=Yuzo |last9=Mosinger |first9=Bedrich |last10=Shirazi-Beechey |first10=Soraya P. |bibcode=2007PNAS..10415075M |doi-access=free }}</ref>
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