Open main menu
Home
Random
Recent changes
Special pages
Community portal
Preferences
About Wikipedia
Disclaimers
Incubator escapee wiki
Search
User menu
Talk
Dark mode
Contributions
Create account
Log in
Editing
Neomycin
(section)
Warning:
You are not logged in. Your IP address will be publicly visible if you make any edits. If you
log in
or
create an account
, your edits will be attributed to your username, along with other benefits.
Anti-spam check. Do
not
fill this in!
==Side effects== In 2005β06, Neomycin was the fifth-most-prevalent allergen in [[patch test]] results (10.0%).<ref>{{cite journal | vauthors = Zug KA, Warshaw EM, Fowler JF, Maibach HI, Belsito DL, Pratt MD, Sasseville D, Storrs FJ, Taylor JS, Mathias CG, Deleo VA, Rietschel RL, Marks J | display-authors = 6 | title = Patch-test results of the North American Contact Dermatitis Group 2005-2006 | journal = Dermatitis | volume = 20 | issue = 3 | pages = 149β60 | year = 2009 | pmid = 19470301 | doi = 10.2310/6620.2009.08097 | s2cid = 24088485 }}</ref> It was named [[Allergen of the Year]] in 2010.<ref>McNamara, Damian. (2010). [http://www.edermatologynews.com/shared/shared-articles/neomycin-is-named-contact-allergen-of-the-year/4d105dda2788039dae9d166eac96393b.html Neomycin Is Named Contact Allergen of the Year] {{Webarchive|url=https://archive.today/20150422003106/http://www.edermatologynews.com/shared/shared-articles/neomycin-is-named-contact-allergen-of-the-year/4d105dda2788039dae9d166eac96393b.html|date=2015-04-22}}</ref> Neomycin is also a known GABA [[gamma-Aminobutyric acid|''gamma''-Aminobutyric acid]] antagonist and can be responsible for seizures and psychosis.<ref name="pmid219730">{{cite journal | vauthors = Lee C, de Silva AJ | title = Interaction of neuromuscular blocking effects of neomycin and polymyxin B | journal = Anesthesiology | volume = 50 | issue = 3 | pages = 218β20 | date = March 1979 | pmid = 219730 | doi = 10.1097/00000542-197903000-00010 | s2cid = 13551808 }}</ref> Like other aminoglycosides, neomycin has been shown to be [[Ototoxicity|ototoxic]], causing [[tinnitus]], hearing loss, and [[vestibular system|vestibular]] problems in a small number of patients. Neomycin affects the cochlea, which is found in the inner ear.<ref name="Langman, A 1994">Langman, A. Neomycin ototoxicity. Otolaryngology Head and Neck Surgery 1994, 110, 441-444.</ref> Hearing loss is caused by ear hair cell death, which occurs in response to treatment with neomycin.<ref name="Langman, A 1994"/> Patients with existing tinnitus or sensorineural hearing loss are advised to speak with a healthcare practitioner about the risks and side effects prior to taking this medication.{{citation needed|date=March 2023}}
Edit summary
(Briefly describe your changes)
By publishing changes, you agree to the
Terms of Use
, and you irrevocably agree to release your contribution under the
CC BY-SA 4.0 License
and the
GFDL
. You agree that a hyperlink or URL is sufficient attribution under the Creative Commons license.
Cancel
Editing help
(opens in new window)