Editing Non-coding RNA (section)

===In RNA splicing===

[[File:Yeast tri-snRNP.jpg|thumb|left|Electron microscopy images of the yeast spliceosome. Note the bulk of the complex is in fact ncRNA.]]

In eukaryotes, the [[spliceosome]] performs the [[RNA splicing|splicing]] reactions essential for removing [[intron]] sequences, this process is required for the formation of mature [[mRNA]].  The [[spliceosome]] is another RNP often known as the [[snRNP]] or tri-snRNP.  There are two different forms of the spliceosome, the major and minor forms.  The ncRNA components of the major spliceosome are [[U1 snRNA|U1]], [[U2 snRNA|U2]], [[U4 snRNA|U4]], [[U5 snRNA|U5]], and [[U6 snRNA|U6]].  The ncRNA components of the minor spliceosome are [[U11 snRNA|U11]], [[U12 snRNA|U12]], [[U5 snRNA|U5]], [[U4atac minor spliceosomal RNA|U4atac]] and [[U6atac minor spliceosomal RNA|U6atac]].{{citation needed|date=June 2017}}

Another group of introns can catalyse their own removal from host transcripts; these are called self-splicing RNAs.  There are two main groups of self-splicing RNAs: [[group I catalytic intron]] and [[group II catalytic intron]]. These ncRNAs catalyze their own excision from mRNA, tRNA and rRNA precursors in a wide range of organisms.{{citation needed|date=June 2017}}

In mammals it has been found that snoRNAs can also regulate the [[alternative splicing]] of mRNA, for example snoRNA [[Small nucleolar RNA SNORD115|HBII-52]] regulates the splicing of [[5-HT2C receptor|serotonin receptor 2C]].<ref name=Kishore>{{cite journal | vauthors = Kishore S, Stamm S | title = The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C | journal = Science | volume = 311 | issue = 5758 | pages = 230–232 | date = January 2006 | pmid = 16357227 | doi = 10.1126/science.1118265 | s2cid = 44527461 | doi-access = free | bibcode = 2006Sci...311..230K }}</ref>

In nematodes, the [[SmY]] ncRNA appears to be involved in mRNA [[trans-splicing]].<ref>{{Cite journal |last1=Jones |first1=Thomas A. |last2=Otto |first2=Wolfgang |last3=Marz |first3=Manja |last4=Eddy |first4=Sean R. |last5=Stadler |first5=Peter F. |date=2009 |title=A survey of nematode SmY RNAs |url=https://pubmed.ncbi.nlm.nih.gov/19106623/ |journal=RNA Biology |volume=6 |issue=1 |pages=5–8 |doi=10.4161/rna.6.1.7634 |issn=1555-8584 |pmid=19106623}}</ref>