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Nootropic
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==Adverse effects== The main concern with [[pharmaceutical drug]]s and dietary supplements are [[adverse effect]]s, including the potential for [[psychological dependence]]. Long-term safety evidence is typically unavailable for many nootropic compounds. [[Racetams]], piracetam and other compounds that are structurally related to piracetam, have few serious adverse effects and low [[toxicity]], but there is little evidence that they enhance cognition in people having no cognitive impairments.<ref name="Racetam efficacy review 2010">{{cite journal | vauthors = Malykh AG, Sadaie MR | title = Piracetam and piracetam-like drugs: from basic science to novel clinical applications to CNS disorders | journal = Drugs | volume = 70 | issue = 3 | pages = 287β312 | date = February 2010 | pmid = 20166767 | doi = 10.2165/11319230-000000000-00000 | s2cid = 12176745 }}</ref> In the United States, dietary supplements may be marketed if the manufacturer can show that the supplement is [[generally recognized as safe]], and if the manufacturer does not make any claims about using the supplement to treat or prevent any disease or condition; supplements that contain drugs or advertise [[health claim]]s are illegal under US law.<ref>{{cite journal | vauthors = Goldman P | title = Herbal medicines today and the roots of modern pharmacology | journal = Annals of Internal Medicine | volume = 135 | issue = 8 Pt 1 | pages = 594β600 | date = October 2001 | pmid = 11601931 | doi = 10.7326/0003-4819-135-8_Part_1-200110160-00010 | s2cid = 35766876 }}</ref>
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