Editing Northern leopard frog (section)

==Research==

===Medical===
The northern leopard frog produces specific [[ribonuclease]]s to its [[oocyte]]s. Those enzymes are potential drugs for [[cancer]]. One such molecule, called [[ranpirnase]] (onconase), is in clinical trials as a treatment for [[pleural]] mesothelioma and [[lung]] tumors. Another, [[amphinase]], has been described as a potential treatment for [[brain]] tumors.<ref>[http://www.eurekalert.org/pub_releases/2007-06/uob-fmc062607.php Frog molecule could provide drug treatment for brain tumors]</ref>

===Neuroscience===
The northern leopard frog has been a preferred species for making discoveries about basic properties of [[neurons]] since the 1950s. The [[neuromuscular junction]] of the [[sciatic nerve]] fibers of the [[sartorius muscle]] of this frog has been the source of initial data about the [[nervous system]].<ref>{{cite journal |pmid=14946732 |year=1952 |last1=Fatt |first1=P |last2=Katz |first2=B |title=Spontaneous subthreshold activity at motor nerve endings |volume=117 |issue=1 |pages=109–28 |pmc=1392564 |journal=The Journal of Physiology|doi=10.1113/jphysiol.1952.sp004735}}</ref><ref>{{cite journal |pmid=13175199 |year=1954 |last1=Del Castillo |first1=J |last2=Katz |first2=B |title=Quantal components of the end-plate potential |volume=124 |issue=3 |pages=560–73 |pmc=1366292 |journal=The Journal of Physiology |doi=10.1113/jphysiol.1954.sp005129}}</ref><ref>{{cite journal |year=1959|last1=Lettvin |first1=J.Y. |last2=Maturana |first2=H.R. |last3=McCulloch |first3=W.S. |last4=Pitts |first4=W.H. |title=What the Frog's Eye Tells the Frog's Brain |volume=47 |issue=11 |pages=1940–51 |journal=Proceedings of the IRE|doi=10.1109/JRPROC.1959.287207 |s2cid=8739509 }}</ref><ref>{{cite journal |pmid=14278409 |year=1965 |last1=Katz |first1=B |last2=Miledi |first2=R |title=The Measurement of Synaptic Delay, and the Time Course of Acetylcholine Release at the Neuromuscular Junction |volume=161 |pages=483–95 |journal=Proceedings of the Royal Society of London. Series B |doi=10.1098/rspb.1965.0016 |issue=985|bibcode=1965RSPSB.161..483K |s2cid=8663912 }}</ref><ref>{{cite journal |pmid=171380 |year=1975 |last1=Kuffler |first1=SW |last2=Yoshikami |first2=D |title=The number of transmitter molecules in a quantum: An estimate from iontophoretic application of acetylcholine at the neuromuscular synapse |volume=251 |issue=2 |pages=465–82 |pmc=1348438 |journal=The Journal of Physiology |doi=10.1113/jphysiol.1975.sp011103}}</ref><ref>{{cite journal |pmid=6033586 |year=1967 |last1=Hille |first1=B |title=The selective inhibition of delayed potassium currents in nerve by tetraethylammonium ion |volume=50 |issue=5 |pages=1287–302 |pmc=2225709 |journal=The Journal of General Physiology |doi=10.1085/jgp.50.5.1287}}</ref><ref>{{cite journal |pmid=4543940 |year=1973 |last1=Anderson |first1=CR |last2=Stevens |first2=CF |title=Voltage clamp analysis of acetylcholine produced end-plate current fluctuations at frog neuromuscular junction |volume=235 |issue=3 |pages=655–91 |pmc=1350786 |journal=The Journal of Physiology |doi=10.1113/jphysiol.1973.sp010410}}</ref>

===Muscle physiology and biomechanics===
The northern leopard frog is a popular species for ''[[in vitro]]'' experiments in [[muscle]] physiology and [[biomechanics]] due to the ease of accessibility for investigators in its native range and the ability of the [[sartorius muscle]] to stay alive ''in vitro'' for several hours. Furthermore, the reliance of the frog on two major modes of locomotion ([[jumping]] and [[Aquatic locomotion|swimming]]) allows for understanding how muscle properties contribute to organismal performance in each of these modes.