Editing Oct-4 (section)

==Implications in disease==
Oct-4 has been implicated in tumorigenesis of adult germ cells.  [[Ectopic expression]] of the factor in adult mice has been found to cause the formation of [[dysplastic lesions]] of the skin and intestine.  The intestinal dysplasia resulted from an increase in progenitor cell population and the upregulation of [[beta-catenin|β-catenin]] transcription through the inhibition of cellular differentiation.<ref>{{cite journal | vauthors = Hochedlinger K, Yamada Y, Beard C, Jaenisch R | title = Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues | journal = Cell | volume = 121 | issue = 3 | pages = 465–77 | date = May 2005 | pmid = 15882627 | doi = 10.1016/j.cell.2005.02.018 | s2cid = 1913872 | doi-access = free }}</ref>