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Orthostatic hypotension
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==Causes== Some causes of orthostatic hypotension include [[Neurodegeneration|neurodegenerative disorders]], [[hypovolemia|low blood volume]] (e.g. caused by [[dehydration]], [[bleeding]], or the use of [[diuretic]]s), drugs that cause [[vasodilation]], other types of drugs (notably, [[narcotic]]s and [[marijuana]]), discontinuation of [[vasoconstrictor]]s, prolonged [[bed rest]] (immobility), significant recent weight loss, [[anemia]],<ref>{{cite web|title=What Causes Hypotension? - |url=https://www.nhlbi.nih.gov/health/health-topics/topics/hyp/causes|work = National Heart, Lung, and Blood Institute (NHLBI) | publisher = U.S. National Institutes of Health |access-date=27 March 2017 }}</ref> [[Vitamin B12 deficiency|vitamin B<sub>12</sub> deficiency]], or recent [[bariatric surgery]].<ref>{{cite journal | vauthors = Christou GA, Kiortsis DN | title = The effects of body weight status on orthostatic intolerance and predisposition to noncardiac syncope | journal = Obesity Reviews | volume = 18 | issue = 3 | pages = 370β379 | date = March 2017 | pmid = 28112481 | doi = 10.1111/obr.12501 | s2cid = 46498296 }}</ref> ===Medication=== [[File:Tetrahydrocannabinol.svg|thumb|160 px|Tetrahydrocannabinol]] Orthostatic hypotension can be a side effect of certain [[antidepressants]], such as [[tricyclic antidepressant|tricyclics]]<ref name=pmid16290952>{{cite journal | vauthors = Jiang W, Davidson JR | title = Antidepressant therapy in patients with ischemic heart disease | journal = American Heart Journal | volume = 150 | issue = 5 | pages = 871β881 | date = November 2005 | pmid = 16290952 | doi = 10.1016/j.ahj.2005.01.041 }}</ref> or [[monoamine oxidase inhibitor]]s (MAOIs)<ref name=pmid12412837>{{cite journal | vauthors = Jones RT | title = Cardiovascular system effects of marijuana | journal = Journal of Clinical Pharmacology | volume = 42 | issue = S1 | pages = 58Sβ63S | date = November 2002 | pmid = 12412837 | doi = 10.1002/j.1552-4604.2002.tb06004.x | s2cid = 12193532 }}</ref> Alcohol can potentiate orthostatic hypotension to the point of [[syncope (medicine)|syncope]].<ref name=pmid10653831>{{cite journal | vauthors = Narkiewicz K, Cooley RL, Somers VK | title = Alcohol potentiates orthostatic hypotension : implications for alcohol-related syncope | journal = Circulation | volume = 101 | issue = 4 | pages = 398β402 | date = February 2000 | pmid = 10653831 | doi = 10.1161/01.CIR.101.4.398 | doi-access = free }}</ref> Orthostatic hypotension can also be a side effect of [[alpha-1 blocker]]s (alpha<sub>1</sub> adrenergic blocking agents). Alpha<sub>1</sub> blockers inhibit vasoconstriction normally initiated by the [[baroreceptor reflex]] upon postural change and the subsequent drop in pressure.<ref>{{cite web | vauthors = Shea MJ, Thompson AD | title = Orthostatic Hypotension | url = https://www.msdmanuals.com/professional/cardiovascular-disorders/symptoms-of-cardiovascular-disorders/orthostatic-hypotension | work = [[Merck Manual]] }}</ref> Other [[antihypertensive drug|antihypertensive medications]] may also cause orthostatic hypotension, in addition to [[anticholinergic]]s, [[dopaminergic]] drugs, [[opiates]] and [[psychoactive drug|psychoactive medications]].<ref name="AAFP Kim" /> ===Other factors=== Patients prone to orthostatic hypotension are the elderly, ''[[post partum]]'' mothers, and those having been on bed rest. People with anorexia nervosa and [[bulimia nervosa]] often develop orthostatic hypotension as a common side effect. Consuming alcohol may also lead to orthostatic hypotension due to its dehydrating effects.{{citation needed | date=April 2015}}
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