Editing PEP group translocation (section)

===Regulation===
With the glucose phosphotransferase system, the phosphorylation status of '''EIIA''' can have regulatory functions. For example, at low glucose concentrations phosphorylated EIIA accumulates and this activates membrane-bound [[adenylate cyclase]]. Intracellular [[cyclic AMP]] levels rise and this then activates '''CAP''' ([[catabolite activator protein]]), which is involved in the [[catabolite repression]] system, also known as glucose effect. When the glucose concentration is high, EIIA is mostly dephosphorylated and this allows it to inhibit [[adenylate cyclase]], [[glycerol kinase]], [[lactose permease]], and [[maltose permease]]. Thus, in addition to being an efficient way to import substrates into the bacterium, the PEP group translocation system also links this transport to regulation of other relevant proteins.

[[File:Phosphotransferase system Serratia marcescens.png|400px|thumb|In ''[[Serratia marcescens]]''.]]