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Palmoplantar keratoderma
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===Punctate=== ''Punctate palmoplantar keratoderma'' is a form of palmoplantar keratoderma in which many tiny "raindrop" keratoses involve the palmoplantar surface, [[skin lesion]]s which may involve the whole of the palmoplantar surface, or may be more restricted in their distribution.<ref name="Fitzpatrick_2003" />{{rp|505}}<ref name="Bolognia_2007" /> * Type 1: ''Keratosis punctata palmaris et plantaris'' (also known as "Autosomal-dominant hereditary punctate keratoderma associated with malignancy", "Buschke–Fischer–Brauer disease", "Davis Colley disease", "Keratoderma disseminatum palmaris et plantaris", "Keratosis papulosa", "Keratoderma punctatum", "Keratodermia punctata", "Keratoma hereditarium dissipatum palmare et plantare", "Palmar and plantar seed dermatoses", "Palmar keratoses", "Papulotranslucent acrokeratoderma", "Punctate keratoderma", "Punctate keratoses of the palms and soles", and "Maculosa disseminata") is a skin condition, an autosomal dominant palmoplantar keratoderma with [[variable penetrance]], characterized clinically by multiple, tiny, punctate keratoses over the entire palmoplantar surfaces, beginning over the lateral edge of the digits.<ref name="Fitzpatrick_2003" />{{rp|509}}<ref name="Andrews_2005" />{{rp|212–213}} It has been linked to 15q22-q24.<ref name="pmid14684683">{{cite journal | vauthors = Martinez-Mir A, Zlotogorski A, Londono D, Gordon D, Grunn A, Uribe E, Horev L, Ruiz IM, Davalos NO, Alayan O, Liu J, Gilliam TC, Salas-Alanis JC, Christiano AM | title = Identification of a locus for type I punctate palmoplantar keratoderma on chromosome 15q22-q24 | journal = Journal of Medical Genetics | volume = 40 | issue = 12 | pages = 872–8 | date = December 2003 | pmid = 14684683 | pmc = 1735333 | doi = 10.1136/jmg.40.12.872 }}</ref> * Type 2: ''Spiny keratoderma'' (also known as "Porokeratosis punctata palmaris et plantaris", "Punctate keratoderma", and "Punctate porokeratosis of the palms and soles") is an autosomal dominant [[keratoderma]] of late onset that develops in patients aged 12 to 50, characterized by multiple tiny keratotic plugs, resembling the spines on a music box, involving the entire palmoplantar surfaces.<ref name="Fitzpatrick_2003" />{{rp|509}}<ref name="Bolognia_2007" /> * Type 3: ''Focal acral hyperkeratosis'' (also known as "Acrokeratoelastoidosis lichenoides", and "Degenerative collagenous plaques of the hand") is a late-onset [[keratoderma]], inherited as an autosomal dominant condition, characterized by oval or polygonal crateriform [[papule]]s developing along the border of the hands, feet, and wrists.<ref name="Fitzpatrick_2003" />{{rp|509}} It is considered similar to Costa acrokeratoelastoidosis.<ref name="pmid15078352">{{cite journal | vauthors = Erkek E, Koçak M, Bozdoğan O, Atasoy P, Birol A | title = Focal acral hyperkeratosis: a rare cutaneous disorder within the spectrum of Costa acrokeratoelastoidosis | journal = Pediatric Dermatology | volume = 21 | issue = 2 | pages = 128–30 | year = 2004 | pmid = 15078352 | doi = 10.1111/j.0736-8046.2004.21208.x | s2cid = 19811383 }}</ref>
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