Editing Paradoxical reaction (section)

===Antidepressants===
{{See also|Antidepressants and suicide risk}}

In a minority of cases, [[antidepressant]]s can lead to violent [[suicidal ideation|thoughts of suicide or self-harm]], as observed in some patients during and after treatment, which is in marked contrast to their intended effect.<ref>{{cite journal | vauthors = Teicher MH, Glod C, Cole JO | title = Emergence of intense suicidal preoccupation during fluoxetine treatment | journal = The American Journal of Psychiatry | volume = 147 | issue = 2 | pages = 207–10 | date = February 1990 | pmid = 2301661 | doi = 10.1176/ajp.147.2.207 }}</ref> A 1991 study found that children and adolescents were more sensitive to paradoxical reactions of self-harm and suicidal ideation while taking [[fluoxetine]] (commonly known as Prozac).<ref>{{cite journal | vauthors = King RA, Riddle MA, Chappell PB, Hardin MT, Anderson GM, Lombroso P, Scahill L | title = Emergence of self-destructive phenomena in children and adolescents during fluoxetine treatment | journal = Journal of the American Academy of Child and Adolescent Psychiatry | volume = 30 | issue = 2 | pages = 179–86 | date = March 1991 | pmid = 2016219 | doi = 10.1097/00004583-199103000-00003 | doi-access = free }}</ref> This can be regarded as a paradoxical reaction but, especially in the case of suicide, may in at least some cases be merely due to differing rates of effect with respect to different symptoms of depression: If generalized overinhibition of a patient's actions enters remission before that patient's dysphoria does and if the patient was already suicidal but too depressed to act on their inclinations, the patient may find themself in the situation of being both still dysphoric enough to want to commit suicide but newly free of endogenous barriers against doing so.{{citation needed|date=January 2024}}