Editing Pemetrexed (section)

==Drug interaction==
The administration of cisplatin and [[vitamin B12|vitamin B<sub>12</sub>]] concomitantly does not modify the [[pharmacokinetics]] of the pemetrexed.
It was recently shown that pemetrexed may play a role in cisplatin resistance in lung cancer by increasing the expression of Orai3 calcium channels as well as the expression of certain ABC transporters like MDR1 and MRP-5 responsible for cisplatin efflux and therefore a reduction of the effect of cisplatin<ref>{{cite bioRxiv |last1=Daoudi |first1=Redoane |date=26 September 2024 |title=Characterization and implication of the Orai3 channel and ABC type transporters in the phenomenon of chemoresistance to cisplatin and pemetrexed in lung cancer. |biorxiv=10.1101/2024.09.22.613742}}</ref>
As current therapies are based on the co-administration of pemetrexed and cisplatin, there may be interactions between pemetrexed and cisplatin, including a reduction in the therapeutic effects of cisplatin caused by pemetrexed.