Editing Progestogen (medication) (section)

===Hormone therapy===

====Menopause and hypogonadism====
Progestogens are used in combination with [[estrogen (medication)|estrogen]]s in [[menopausal hormone therapy]] in women. They are also used in combination with estrogens in hormone therapy for [[hypogonadism]] and [[delayed puberty]] in girls and women. They are used mainly to prevent [[endometrial hyperplasia]] and increased risk of [[endometrial cancer]] from unopposed estrogen therapy.

====Transgender hormone therapy====
Progestogens are used as a component of [[transgender hormone therapy|hormone therapy]] for [[transgender women]] and [[transgender men]]. They are used in transgender women in combination with estrogens to help suppress and block [[testosterone]]. Progestogens might also have other beneficial effects in transgender women, but these are controversial and unsupported at present. Examples of progestogens used in hormone therapy for transgender women include [[cyproterone acetate]], [[medroxyprogesterone acetate]], and [[progesterone (medication)|progesterone]]. Progestogens, such as medroxyprogesterone and [[lynestrenol]], are used in transgender men to help suppress [[menses]]. Progestogens have also been used to delay [[puberty]] in [[transgender youth|transgender boys and girls]].

====Other uses====
Certain progestogens, including [[megestrol acetate]], medroxyprogesterone acetate, cyproterone acetate, and [[chlormadinone acetate]], have been used at high doses to reduce [[hot flash]]es in men undergoing [[androgen deprivation therapy]], for instance to treat [[prostate cancer]].<ref name="pmid18231613">{{cite journal | vauthors = Guise TA, Oefelein MG, Eastham JA, Cookson MS, Higano CS, Smith MR | title = Estrogenic side effects of androgen deprivation therapy | journal = Rev Urol | volume = 9 | issue = 4 | pages = 163–80 | year = 2007 | pmid = 18231613 | pmc = 2213888}}</ref><ref name="pmid19962840">{{cite journal | vauthors = Frisk J | title = Managing hot flushes in men after prostate cancer--a systematic review | journal = Maturitas | volume = 65 | issue = 1 | pages = 15–22 | year = 2010 | pmid = 19962840 | doi = 10.1016/j.maturitas.2009.10.017| doi-access = free }}</ref><ref name="pmid24223412">{{cite journal | vauthors = Koike H, Morikawa Y, Matsui H, Shibata Y, Ito K, Suzuki K | title = Chlormadinone acetate is effective for hot flush during androgen deprivation therapy | journal = Prostate Int | volume = 1 | issue = 3 | pages = 113–6 | year = 2013 | pmid = 24223412 | pmc = 3814123 | doi = 10.12954/PI.12010}}</ref>