Editing Protein isoform (section)

==Related concepts==

=== Glycoform ===
{{main|Glycoprotein}}

A '''glycoform''' is an isoform of a protein that differs only with respect to the number or type of attached [[glycan]]. [[Glycoproteins]] often consist of a number of different glycoforms, with alterations in the attached [[saccharide]] or [[oligosaccharide]]. These modifications may result from differences in [[biosynthesis]] during the process of [[glycosylation]], or due to the action of [[glycosidases]] or [[glycosyltransferases]]. Glycoforms may be detected through detailed chemical analysis of separated glycoforms, but more conveniently detected through differential reaction with [[lectins]], as in [[lectin affinity chromatography]] and [[lectin]] [[affinity electrophoresis]]. Typical examples of glycoproteins consisting of glycoforms are the [[blood proteins]] as [[orosomucoid]], [[antitrypsin]], and [[haptoglobin]]. An unusual glycoform variation is seen in [[neural cell adhesion molecule|neuronal cell adhesion molecule, NCAM]] involving [[polysialic acid|polysialic acids, PSA]].