Editing Retinoid (section)

==Uses==
Common skin conditions treated by topical retinoids include acne, [[psoriasis]],<ref>{{cite web|url=http://www.psoriasis.org/netcommunity/sublearn03_severe_acitretin|title=Systemic medications: Soriatane (acitretin) |publisher=National Psoriasis Foundation|access-date=16 March 2018|url-status=dead|archive-url=https://web.archive.org/web/20100613052050/http://psoriasis.org/netcommunity/sublearn03_severe_acitretin|archive-date=13 June 2010}}</ref><ref>{{cite web |url=http://www.mayoclinic.org/diseases-conditions/psoriasis/basics/treatment/con-20030838 |title=Psoriasis - Diagnosis and treatment |publisher=Mayo Clinic |access-date=16 March 2018 |url-status=live |archive-url=https://web.archive.org/web/20170507231658/http://www.mayoclinic.org/diseases-conditions/psoriasis/basics/treatment/con-20030838 |archive-date=7 May 2017 }}</ref> and effects of photoaging.<ref>{{cite journal | vauthors = Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G | title = Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety | journal = Clinical Interventions in Aging | volume = 1 | issue = 4 | pages = 327–348 | date = 2006 | pmid = 18046911 | pmc = 2699641 | doi = 10.2147/ciia.2006.1.4.327 | doi-access = free}}</ref><ref>{{cite journal | vauthors = Kafi R, Kwak HS, Schumacher WE, Cho S, Hanft VN, Hamilton TA, King AL, Neal JD, Varani J, Fisher GJ, Voorhees JJ, Kang S  | title = Improvement of naturally aged skin with vitamin A (retinol) | journal = Archives of Dermatology | volume = 143 | issue = 5 | pages = 606–612 | date = May 2007 | pmid = 17515510 | doi = 10.1001/archderm.143.5.606 | doi-access = free }}</ref> In addition, retinoids are used to treat some rare skin disorders, including [[Discoid lupus erythematosus|discoid lupus]]<ref>{{cite journal | vauthors = Laosakul K, Chiewchanvit S, Chuamanochan M, Tovanabutra N | title = Acitretin treatment in antimalarial-refractory/intolerant discoid lupus erythematosus: A prospective, open-label, uncontrolled study | journal = Lupus | volume = 31 | issue = 5 | pages = 575–581 | date = April 2022 | pmid = 35306922 | doi = 10.1177/09612033221086878 }}</ref> and [[mycosis fungoides]].<ref>{{cite journal | vauthors = Panchal MR, Scarisbrick JJ | title = The utility of bexarotene in mycosis fungoides and Sézary syndrome | journal = OncoTargets and Therapy | volume = 8 | pages = 367–373 | date = 2015-02-03 | pmid = 25678803 | pmc = 4322887 | doi = 10.2147/OTT.S61308 | doi-access = free }}</ref> In Japan, isotretinoin may be used for [[neuroblastoma]] treatment,<ref>{{cite journal | vauthors = Makimoto A, Fujisaki H, Matsumoto K, Takahashi Y, Cho Y, Morikawa Y, Yuza Y, Tajiri T, Iehara T  | title = Retinoid Therapy for Neuroblastoma: Historical Overview, Regulatory Challenges, and Prospects | journal = Cancers | volume = 16 | issue = 3 | pages = 544 | date = January 2024 | pmid = 38339295 | pmc = 10854948 | doi = 10.3390/cancers16030544 | doi-access = free }}</ref> but it is not approved in other countries due to a lack of consistency in studies of its effectiveness.<ref>{{cite journal | vauthors = Makimoto A, Fujisaki H, Matsumoto K, Takahashi Y, Cho Y, Morikawa Y, Yuza Y, Tajiri T, Iehara T  | title = Retinoid Therapy for Neuroblastoma: Historical Overview, Regulatory Challenges, and Prospects | journal = Cancers | volume = 16 | issue = 3 | pages = 544 | date = January 2024 | pmid = 38339295 | pmc = 10854948 | doi = 10.3390/cancers16030544 | doi-access = free }}</ref> Oral retinoids are readily toxic, requiring consistent clinical oversight, and are approved in several diseases for which said toxicity is paradoxically useful, including [[acute promyelocytic leukemia]], [[cutaneous T-cell lymphoma]], and [[heterotopic ossification]].<ref>{{cite journal | vauthors = Esposito M, Amory JK, Kang Y | title = The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes | journal = The Journal of Experimental Medicine | volume = 221 | issue = 9 | date = September 2024 | pmid = 39133222 | doi = 10.1084/jem.20240519 | doi-access = free | pmc = 11318670 }}</ref>