Editing Saltatory conduction (section)

==History of research==
In 1925 Ralph S. Lillie proposed the mechanism of saltatory conduction after experimenting with an iron wire model of the nerve, after covering the wire with isolated sections akin to myelinated internodes he observed a faster and "saltatory" conduction.<ref>{{Cite journal |last=Young |first=Robert G. |last2=Castelfranco |first2=Ann M. |last3=Hartline |first3=Daniel K. |date=June 2013 |title=The “Lillie Transition”: models of the onset of saltatory conduction in myelinating axons |url=http://link.springer.com/10.1007/s10827-012-0435-3 |journal=Journal of Computational Neuroscience |language=en |volume=34 |issue=3 |pages=533–546 |doi=10.1007/s10827-012-0435-3 |issn=0929-5313|hdl=10125/24451 |hdl-access=free }}</ref>

In 1939, [[Ichiji Tasaki]] confirmed saltatory conduction through experiments on isolated [[Nerve|single-nerve fibers]] of the [[Japanese common toad|Japanese Toad]].<ref>{{cite journal |last1=Tasaki |first1=Ichiji |title=Electric Stimulation and the Excitatory Process in the Nerve Fiber |journal=American Journal of Physiology |date=31 Jan 1939 |volume=125 |issue=2|pages=380–395 |doi=10.1152/ajplegacy.1939.125.2.380 }}</ref> Tasaki was experimenting with anaesthetics and noticed a lack of conduction when three or more nodes were anesthetized, leading to his hypothesis.<ref name="auto">{{cite journal |last1=Boullerne |first1=Anne Isabelle |title=The history of myelin |journal=Exp Neurol |date=Sep 2016 |volume=283 |issue=Pt B |pages=431–445 |doi=10.1016/j.expneurol.2016.06.005 |pmid=27288241 |pmc=5010938 }}</ref> During World War II, Tasaki was not able to publish in American journals and had to send manuscripts to Germany via the Siberian railroad. He only heard of their publication after the war ended.<ref name="auto"/>

Lillie's hypothesis was also confirmed by [[Andrew Huxley]] and Robert Stämpfli in peripheral myelinated nerve fibers in 1949 through experiments with isolated frog nerves.<ref>{{cite journal |last1=Huxley AF, Stämpfli R |title=Evidence for saltatory conduction in peripheral myelinated nerve fibres |journal=J Physiol |date=May 15, 1949  |volume=108|issue=3 |pages=315–339 |doi=10.1113/jphysiol.1949.sp004335 }}</ref> Bernhard Frankenhaeuser proved that this was true in undissected frog nerves as well, ending scholarly debate.<ref>{{cite journal |last1=FRANKENHAEUSER |first1=BERNHARD |title=Saltatory conduction in myelinated nerve fibres |journal=J Physiol |date=Sep 1952 |volume=118 |issue=1 |pages=107–112 |doi=10.1113/jphysiol.1952.sp004776 |pmid=13000694 |pmc=1392427 }}</ref>