Editing Somatic nervous system (section)

==Clinical Significance==
A medical condition known as [[peripheral neuropathy]] affects the somatic nervous system's peripheral nerve fibers.
They can be divided into congenital and acquired disorders based on the causes. They can also be categorized based on whether the [[myelin sheath]](demyelinating neuropathy) or axons (axonal neuropathy) have the predominant disease. There is a wide range of causes for axonal peripheral neuropathy, most of which are toxic-metabolic in origin and include group B vitamin deficiencies and diabetes.
Demyelinating neuropathies do not vary with length. They are frequently immune-mediated, which causes a more widespread involvement of sensorimotor function and an early loss of deep tendon reflexes. When joint position and vibratory sensory loss are present, sensory participation is more selective.

Defects in the [[central nervous system]], peripheral nervous system, or muscle itself are the cause of numerous congenital illnesses of sensory and motor function.
Owing to the vast territory encompassed by the somatic nerve system, these ailments may manifest as localized in nature, or as broad and systemic. [[Charcot-Marie-Tooth disease]], [[Myasthenia gravis]], and [[Guillain–Barré syndrome]] are a few instances of them.<ref>{{cite book | vauthors = Waxenbaum JA, Reddy V, Varacallo M | chapter = Anatomy, Autonomic Nervous System |date=2024 | title = StatPearls | chapter-url= http://www.ncbi.nlm.nih.gov/books/NBK539845/ |access-date=2024-01-26 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=30969667 }}</ref>

=== Charcot-Marie-Tooth (CMT) ===
The Charcot-Marie-Tooth (CMT) disease group comprises diverse hereditary illnesses that manifest as chronic, progressive neuropathy that affects both the motor and sensory neurons.<ref>{{cite journal | vauthors = Szigeti K, Lupski JR | title = Charcot-Marie-Tooth disease | journal = European Journal of Human Genetics | volume = 17 | issue = 6 | pages = 703–710 | date = June 2009 | pmid = 19277060 | pmc = 2947101 | doi = 10.1038/ejhg.2009.31 }}
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=== Myasthenia Gravis (MG) ===
An autoimmune neurological condition called myasthenia gravis (MG) is typified by impaired neuromuscular junction communication.<ref>{{cite journal | vauthors = Dresser L, Wlodarski R, Rezania K, Soliven B | title = Myasthenia Gravis: Epidemiology, Pathophysiology and Clinical Manifestations | journal = Journal of Clinical Medicine | volume = 10 | issue = 11 | pages = 2235 | date = May 2021 | pmid = 34064035 | pmc = 8196750 | doi = 10.3390/jcm10112235 | doi-access = free }}</ref>

=== Guillain-Barré syndrome (GBS) ===
A rare but dangerous post-infectious immune-mediated neuropathy is Guillain-Barré syndrome (GBS). It is brought on by an autoimmune reaction that destroys peripheral nervous system nerves, leading to symptoms including tingling, weakness, and numbness that can become paralysis.<ref>{{cite book | vauthors = Nguyen TP, Taylor RS | chapter = Guillain-Barre Syndrome |date=2024 | title = StatPearls | chapter-url= http://www.ncbi.nlm.nih.gov/books/NBK532254/ |access-date=2024-01-26 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=30335287 }}</ref>