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Total synthesis
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==List of notable total syntheses== * [[Quinine total synthesis]]<ref>{{cite journal | vauthors = Halford B | date = 10 April 2017 | volume = 95 | issue = 15 | url = https://cen.acs.org/articles/95/i15/Remembering-organic-chemistry-legend-Robert-Burns-Woodward.html | title = Remembering Organic Chemistry Legend Robert Burns Woodward | journal = C&EN }}</ref><ref name=Nicolaou1 /> First synthesized by Robert Burns Woodward and William von Eggers Doering in 1944, this achievement was significant due to quinine's importance as an antimalarial drug. * [[Strychnine total synthesis]] First synthesized by Robert Burns Woodward in 1954, this synthesis was a landmark achievement due to the molecule's structural complexity. *[[ Morphine total synthesis|Morphine]]: First synthesized by Marshall D. Gates in 1952, with subsequent more efficient syntheses developed by other chemists, including Toshiaki Fukuyama in 2017. * [[Cholesterol total synthesis]]<ref>{{cite journal | vauthors = Mulheirn G | title = Robinson, Woodward and the synthesis of cholesterol. | journal = Endeavour | date = September 2000 | volume = 24 | issue = 3 | pages = 107β110 | doi = 10.1016/S0160-9327(00)01310-7 }}</ref> Synthesized by Robert Burns Woodward in 1951, this was a significant achievement in steroid synthesis. * [[Cortisone]]: Another notable steroid synthesis by Robert Burns Woodward in 1951. * [[Lysergic acid]]: Synthesized by Robert Burns Woodward in 1954, this was an important precursor to LSD. * [[Reserpine]]: Completed by Robert Burns Woodward in 1956, this synthesis was notable for its complexity and the molecule's importance as an antihypertensive drug. * [[Chlorophyll]]: Synthesized by Robert Burns Woodward in 1960, this achievement was significant due to chlorophyll's crucial role in photosynthesis. * [[Colchicine]]: Another notable synthesis by Robert Burns Woodward, completed in 1963. * Prostaglandin F-2a: Synthesized by E.J. Corey in 1969, this was an important achievement in the synthesis of prostaglandins. * [[Vitamin B12 total synthesis|Vitamin B<sub>12</sub> total synthesis]]<ref>{{cite book | vauthors = Rao RB |date=2016 |title=Logic of Organic Synthesis |publisher=LibreTexts |url= https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Logic_of_Organic_Synthesis_(Rao)/13%3A_Synthesis_of_Vitamin_B }}</ref> Completed by Robert Burns Woodward and his team in 1972, this synthesis is considered one of the most complex ever achieved, involving over 100 steps. * [[Paclitaxel total synthesis|Paclitaxel (Taxol) total synthesis]]: First synthesized by Robert A. Holton in 1994, and later by [[K. C. Nicolaou]] in 1995, this anticancer drug's synthesis was a major breakthrough in medicinal chemistry. * [[Brefeldin A]]: Synthesized by S. Raghavan in 2017, this complex macrolide has potential as an anticancer agent. * [[Ryanodine]]: Synthesized by Sarah E. Reisman in 2017, this complex diterpenoid has important biological activity.
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