Editing Transient receptor potential channel (section)

===TRPML===
{| class="wikitable"
!Family
!Sub-Family
!Known Taxa<ref name="Peng" /><ref name="Garcia TRML">{{cite book | vauthors = García-Añoveros J, Wiwatpanit T | chapter = TRPML2 and Mucolipin Evolution | title = Mammalian Transient Receptor Potential (TRP) Cation Channels | series = Handbook of Experimental Pharmacology | volume = 222 | pages = 647–58 | date = 2014 | pmid = 24756724 | doi = 10.1007/978-3-642-54215-2_25 | isbn = 978-3-642-54214-5 }}</ref>
|-
| rowspan="4" |TRPML
|Unknown
| Cnidarians, basal vertebrates, [[tunicates]], [[cephalochordates]], [[hemichordates]], echinoderms, arthropods, and nematodes
|-
|[[MCOLN1|TRPML1]]
| rowspan="3" |Specific to jawed vertebrates
|-
|[[MCOLN2|TRPML2]]
|-
|[[MCOLN3|TRPML3]]
|}
TRPML, ML for "mucolipin", gets its name from the neurodevelopmental disorder [[Mucolipidosis type IV|mucolipidosis IV]]. Mucolipidosis IV was first discovered in 1974 by E.R. Berman who noticed abnormalities in the eyes of an infant.<ref>{{cite journal | vauthors = Berman ER, Livni N, Shapira E, Merin S, Levij IS | title = Congenital corneal clouding with abnormal systemic storage bodies: a new variant of mucolipidosis | journal = The Journal of Pediatrics | volume = 84 | issue = 4 | pages = 519–26 | date = April 1974 | pmid = 4365943 | doi = 10.1016/s0022-3476(74)80671-2 }}</ref> These abnormalities soon became associated with mutations to the MCOLN1 gene which encodes for the TRPML1 ion channel. TRPML is still not highly characterized.  The three known vertebrate copies are restricted to jawed vertebrates, with some exceptions (e.g. ''[[Xenopus tropicalis]]'').<ref name="Garcia TRML" />