Editing Tryptamine (section)

== Metabolism ==

=== Biosynthesis ===
To yield tryptamine ''in vivo'', tryptophan decarboxylase removes the carboxylic acid group on the α-carbon of [[tryptophan]].<ref name=":03"/> Synthetic modifications to tryptamine can produce [[serotonin]] and [[melatonin]]; however, these pathways do not occur naturally as the main pathway for endogenous neurotransmitter synthesis.<ref>{{Cite web|date=2020|title=Serotonin Synthesis and Metabolism|url=https://www.sigmaaldrich.com/technical-documents/articles/biology/rbi-handbook/non-peptide-receptors-synthesis-and-metabolism/serotonin-synthesis-and-metabolism.html|website=Sigma Aldrich}}</ref>

=== Catabolism ===
[[Monoamine oxidase]]s A and B are the primary enzymes involved in tryptamine metabolism to produce [[indole-3-acetaldehyde]], however it is unclear which isoform is specific to tryptamine degradation.<ref>{{Cite web|title=MetaCyc L-tryptophan degradation VI (via tryptamine)|url=https://biocyc.org/META/new-image?object=PWY-3181|access-date=2020-12-11|website=biocyc.org}}</ref>

=== Figure ===
[[File:Biosynthesis and degradation of tryptamine.png|class=skin-invert-image|thumb|none|600px|Conversion of tryptophan to tryptamine, followed by its degradation to indole-3-acetic acid.]]