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Urea cycle
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=== Steps of the urea cycle === # Carbamoyl phosphate is converted to [[citrulline]]. With catalysis by [[ornithine transcarbamylase]], the carbamoyl phosphate group is donated to ornithine and releases a phosphate group.<ref name=":0" /> # A [[condensation reaction]] occurs between the amino group of aspartate and the carbonyl group of citrulline to form [[argininosuccinic acid|argininosuccinate]]. This reaction is ATP dependent and is catalyzed by [[Argininosuccinate synthase|argininosuccinate synthetase]].<ref name=":0" /> # Argininosuccinate undergoes cleavage by [[Argininosuccinate lyase|argininosuccinase]] to form [[arginine]] and [[fumarate]].<ref name=":0" /> # Arginine is cleaved by [[arginase]] to form urea and ornithine. The ornithine is then transported back to the mitochondria to begin the urea cycle again.<ref name=":0" /><ref name=":3" />
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