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X-linked recessive inheritance
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===Most common=== The most common X-linked recessive disorders are:<ref name=gpnotebook>[http://www.gpnotebook.co.uk/simplepage.cfm?ID=-1341784030 GP Notebook - X-linked recessive disorders] {{webarchive|url=https://web.archive.org/web/20110613144555/http://www.gpnotebook.co.uk/simplepage.cfm?ID=-1341784030 |date=2011-06-13 }} Retrieved on 5 Mars, 2009</ref> * [[Red–green color blindness]], also known as daltonism,<ref>{{cite web|url=https://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=303800|title=OMIM Color Blindness, Deutan Series; CBD|website=nih.gov|access-date=3 May 2018|url-status=live|archive-url=https://web.archive.org/web/20090929025156/http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=303800|archive-date=29 September 2009}}</ref> which affects roughly 7% to 10% of men and 0.49% to 1% of women. Its relative benignity may explain its commonness. * [[Hemophilia A]], a [[coagulation|blood clotting]] disorder caused by a [[mutation]] of the [[Factor VIII]] [[gene]] and leading to a deficiency of Factor VIII. It was once thought to be the "royal disease" found in the descendants of Queen Victoria. This is now known to have been Hemophilia B (see below).<ref>{{cite web|author= Michael Price|title= Case Closed: Famous Royals Suffered From Hemophilia|url= https://www.science.org/content/article/case-closed-famous-royals-suffered-hemophilia|work= ScienceNOW Daily News|publisher= AAAS|date= 8 October 2009|access-date= 9 October 2009|url-status= live|archive-url= https://web.archive.org/web/20131020190735/http://news.sciencemag.org/biology/2009/10/case-closed-famous-royals-suffered-hemophilia|archive-date= 20 October 2013}}</ref><ref>{{cite journal |last1=Rogaev |first1=Evgeny I. |last2=Grigorenko |first2=Anastasia P. |last3=Faskhutdinova |first3=Gulnaz |last4=Kittler |first4=Ellen L. W. |last5=Moliaka |first5=Yuri K. |year=2009 |title=Genotype Analysis Identifies the Cause of the 'Royal Disease' |journal=Science |volume=326 |issue=5954 |pages=817 |bibcode=2009Sci...326..817R |doi=10.1126/science.1180660 |pmid=19815722|s2cid=206522975 |doi-access=free }}</ref> * [[Hemophilia B]], also known as Christmas disease,<ref>[http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=181&contentid=46&rptname=bleeding "Hemophilia B".] {{webarchive|url=https://web.archive.org/web/20071201092338/http://www.hemophilia.org/NHFWeb/MainPgs/MainNHF.aspx?menuid=181&contentid=46&rptname=bleeding |date=2007-12-01 }} National Hemophilia Foundation.</ref> a [[coagulation|blood clotting]] disorder caused by a [[mutation]] of the [[Factor IX]] [[gene]] and leading to a deficiency of Factor IX. It is rarer than [[hemophilia A]]. As noted above, it was [[Haemophilia in European royalty|common]] among the descendants of Queen Victoria. * [[Duchenne muscular dystrophy]], which is associated with mutations in the [[dystrophin]] gene. It is characterized by rapid progression of muscle degeneration, eventually leading to loss of skeletal muscle control, respiratory failure, and death. * [[Becker's muscular dystrophy]], a milder form of Duchenne, which causes slowly progressive muscle weakness of the legs and [[pelvis]]. * [[X-linked ichthyosis]], a form of [[ichthyosis]] caused by a [[genetic disorder|hereditary deficiency]] of the [[steroid sulfatase]] (STS) enzyme. It is fairly rare, affecting one in 2,000 to one in 6,000 males.<ref name=PedDerm>{{cite book |author1=Carlo Gelmetti |author2=Caputo, Ruggero |title=Pediatric Dermatology and Dermatopathology: A Concise Atlas |publisher=T&F STM |year=2002 |isbn=1-84184-120-X |page=160}} </ref> * [[X-linked agammaglobulinemia]] (XLA), which affects the body's ability to fight infection. XLA patients do not generate mature [[B cell]]s.<ref name="titleX-linked Agammaglobulinemia: Immunodeficiency Disorders: Merck Manual Professional">{{cite web |url=http://www.merck.com/mmpe/sec13/ch164/ch164o.html |title=X-linked Agammaglobulinemia: Immunodeficiency Disorders: Merck Manual Professional |access-date=2008-03-01 |url-status=live |archive-url=https://web.archive.org/web/20080218140736/http://www.merck.com/mmpe/sec13/ch164/ch164o.html |archive-date=2008-02-18 }}</ref> B cells are part of the immune system and normally manufacture antibodies (also called [[immunoglobulin]]s) which defends the body from infections (the [[humoral]] response). Patients with untreated XLA are prone to develop serious and even fatal infections.<ref name=ConleyXLA>{{cite web|url=http://www.stjude.org/disease-summaries/0,2557,449_2164_6526,00.html|title=Diseases Treated at St. Jude|website=stjude.org|access-date=3 May 2018|url-status=live|archive-url=https://web.archive.org/web/20070815195658/http://www.stjude.org/disease-summaries/0,2557,449_2164_6526,00.html|archive-date=15 August 2007}}</ref> * [[Glucose-6-phosphate dehydrogenase deficiency]], which causes nonimmune hemolytic anemia in response to a number of causes, most commonly infection or exposure to certain medications, chemicals, or foods. Commonly known as "favism", as it can be triggered by chemicals existing naturally in broad (or fava) beans.<ref>{{cite web|url=http://patient.info/doctor/favism|title=Favism - Doctor|website=patient.info|access-date=3 May 2018|url-status=live|archive-url=https://web.archive.org/web/20171121185504/https://patient.info/doctor/favism|archive-date=21 November 2017}}</ref>
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