Editing DNA sequencing (section)

=== Tunnelling currents DNA sequencing ===
Another approach uses measurements of the electrical tunnelling currents across single-strand DNA as it moves through a channel. Depending on its electronic structure, each base affects the tunnelling current differently,<ref>{{cite journal | vauthors = Xu M, Endres RG, Arakawa Y  | title = The electronic properties of DNA bases | journal = Small | volume = 3 | issue = 9 | pages = 1539–43 | year = 2007 | pmid = 17786897 | doi = 10.1002/smll.200600732| doi-access = free }}</ref> allowing differentiation between different bases.<ref>{{cite journal | vauthors = Di Ventra M | title = Fast DNA sequencing by electrical means inches closer | journal = Nanotechnology | volume = 24 | issue = 34 | page = 342501 | year = 2013 | pmid = 23899780 | doi = 10.1088/0957-4484/24/34/342501 | bibcode = 2013Nanot..24H2501D | s2cid = 140101884 | url = https://zenodo.org/record/896777 }}</ref>

The use of tunnelling currents has the potential to sequence orders of magnitude faster than ionic current methods and the sequencing of several DNA oligomers and micro-RNA has already been achieved.<ref name="pmid22787559">{{cite journal | vauthors = Ohshiro T, Matsubara K, Tsutsui M, Furuhashi M, Taniguchi M, Kawai T | title = Single-molecule electrical random resequencing of DNA and RNA | journal = Sci Rep | volume = 2 | page = 501 | year = 2012 | pmid = 22787559 | pmc = 3392642 | doi = 10.1038/srep00501 |bibcode = 2012NatSR...2..501O}}</ref>