Editing Platelet (section)

===Wound repair===

{{Main|Wound repair}}
The blood clot is only a temporary solution to stop bleeding; tissue repair is needed. Small interruptions in the endothelium are handled by physiological mechanisms; large interruptions by a trauma surgeon.<ref>{{cite book |last1=Nguyen |first1=D.T. |last2=Orgill |first2=D.P. |last3=Murphy |first3=G.F. |chapter=4. The Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration |chapter-url=https://www.sciencedirect.com/science/article/pii/B9781845693633500043 |doi=10.1533/9781845695545.1.25 |oclc=844452405 |title=Biomaterials For Treating Skin Loss |publisher=CRC Press |date=2009 |isbn=978-1-4200-9989-8 |pages=25–57 |url=}}</ref> The fibrin is slowly dissolved by the fibrinolytic enzyme, [[plasmin]], and the platelets are cleared by [[phagocytosis]].<ref name="pmid4957257">{{cite journal |author4-link=James Fraser Mustard |vauthors=Movat HZ, Weiser WJ, Glynn MF, Mustard JF |title=Platelet phagocytosis and aggregation |journal=The Journal of Cell Biology |volume=27 |issue=3 |pages=531–543 |date=December 1965 |pmid=4957257 |pmc=2106759 |doi=10.1083/jcb.27.3.531}}</ref>

Platelets release [[platelet-derived growth factor]] (PDGF), a potent [[chemotaxis|chemotactic]] agent; and [[TGF beta]], which stimulates the deposition of [[extracellular matrix]]; [[fibroblast growth factor]], [[insulin-like growth factor 1]], platelet-derived [[epidermal growth factor]], and [[vascular endothelial growth factor]]. Local application of these factors in increased concentrations through [[platelet-rich plasma]] (PRP) is used as an adjunct in wound healing.<ref>{{cite journal |vauthors=Gawaz M, Vogel S |title=Platelets in tissue repair: control of apoptosis and interactions with regenerative cells |journal=Blood |volume=122 |issue=15 |pages=2550–4 |date=October 2013 |pmid=23963043 |doi=10.1182/blood-2013-05-468694 |doi-access=free}}</ref>