Editing Multiple sclerosis (section)

=== Human endogenous retroviruses ===
Two members of the human endogenous retroviruses-W ([[HERV]]-W) family, namely, ERVWE1 and MS-associated retrovirus (MSRV), may be co-factors in MS immunopathogenesis. HERVs constitute up to 8% of the human genome; most are epigenetically silent, but can be reactivated by exogenous viruses, proinflammatory conditions or oxidative stress.<ref>{{cite journal | vauthors = Morandi E, Tanasescu R, Tarlinton RE, Constantinescu CS, Zhang W, Tench C, Gran B | title = The association between human endogenous retroviruses and multiple sclerosis: A systematic review and meta-analysis | journal = PLOS ONE | volume = 12 | issue = 2 | pages = e0172415 | date = 2017-02-16 | pmid = 28207850 | pmc = 5313176 | doi = 10.1371/journal.pone.0172415 | bibcode = 2017PLoSO..1272415M | veditors = Ruprecht K | doi-access = free }}</ref><ref>{{Cite journal |vauthors=Li Y, Fan T, Cui J |date=March 2022 |title=Human endogenous retroviruses in viral disease and therapy |journal=Clinical and Translational Discovery |language=en |volume=2 |issue=1 |doi=10.1002/ctd2.38 |s2cid=247750447 |doi-access=free }}</ref><ref>{{cite journal | vauthors = Rangel SC, da Silva MD, da Silva AL, Dos Santos JM, Neves LM, Pedrosa A, Rodrigues FM, Trettel CD, Furtado GE, de Barros MP, Bachi AL, Romano CM, Nali LH | title = Human endogenous retroviruses and the inflammatory response: A vicious circle associated with health and illness | journal = Frontiers in Immunology | volume = 13 | pages = 1057791 | date = 2022-11-23 | pmid = 36518758 | pmc = 9744114 | doi = 10.3389/fimmu.2022.1057791 | doi-access = free }}</ref>