Editing 20-Hydroxyecdysone (section)

===Use as supplement===
20-Hydroxyecdysone and other ecdysteroids are marketed as ingredients in [[nutritional supplement]]s for various sports, particularly [[bodybuilding]].<ref>{{cite journal | vauthors = Cohen PA, Sharfstein J, Kamugisha A, Vanhee C | title = Analysis of Ingredients of Supplements in the National Institutes of Health Supplement Database Marketed as Containing a Novel Alternative to Anabolic Steroids | journal = JAMA Network Open | volume = 3 | issue = 4 | pages = e202818 | date = April 2020 | pmid = 32293681 | doi = 10.1001/jamanetworkopen.2020.2818 | pmc = 7160690 }}</ref> Although a number of early studies supported the anabolic effects of 20-hydroxyecdysone,<ref>{{cite journal | vauthors = Simakin SY | title = The Combined Use of Ecdisten and the Product'Bodrost'during Training in Cyclical Types of Sport. | journal = Scientific Sports Bulletin | date = 1988 | pages = 2 }}</ref><ref>{{cite journal | vauthors = Gadzhieva RM, Portugalov SN, Paniushkin VV, Kondrat'eva II | title = [A comparative study of the anabolic action of ecdysten, leveton and Prime Plus, preparations of plant origin.] | journal = Eksperimental'naia i Klinicheskaia Farmakologiia | date = 1995 | volume = 58 | issue = 5 | pages = 46–8 | pmid = 8704590 }}</ref><ref name="pmid18220764">{{cite journal | vauthors = Báthori M, Tóth N, Hunyadi A, Márki A, Zádor E | title = Phytoecdysteroids and anabolic-androgenic steroids--structure and effects on humans | journal = Current Medicinal Chemistry | volume = 15 | issue = 1 | pages = 75–91 | date = 2008 | pmid = 18220764 | doi = 10.2174/092986708783330674 | url = http://publicatio.bibl.u-szeged.hu/10883/1/2008_Bathori_et_al._CMC_u.pdf }}</ref><ref>{{cite report | vauthors = Smetanin BY | title = The influence of preparations of plant origin on physical work capacity. | publisher = The Russian Ministry of Public Health | date = 1986 }}</ref><ref>{{cite report | vauthors = Fadeev BG | title = Comments on the Results of Retibol in the Practice of Athletic Training and Rehabilitation | publisher = Natural Sports Research Institute }}</ref><ref name="pmid9575416">{{cite journal | vauthors = Azizov AP, Seĭfulla RD, Ankudinova IA, Kondrat'eva II, Borisova IG | title = [The effect of the antioxidants elton and leveton on the physical work capacity of athletes] | language = ru | journal = Eksperimental'naia i Klinicheskaia Farmakologiia | volume = 61 | issue = 1 | pages = 60–2 | date = 1998 | pmid = 9575416 }}</ref> a 2006 study concluded that the use of 30&nbsp;mg per day of 20-hydroxyecdysone administered orally did not significantly affect [[anabolic]] or [[catabolic]] responses to [[resistance training]], [[body composition]], or training adaptations.<ref>{{cite journal | vauthors = Wilborn CD, Taylor LW, Campbell BI, Kerksick C, Rasmussen CJ, Greenwood M, Kreider RB | title = Effects of methoxyisoflavone, ecdysterone, and sulfo-polysaccharide supplementation on training adaptations in resistance-trained males | journal = Journal of the International Society of Sports Nutrition | volume = 3 | issue = 2 | pages = 19–27 | date = December 2006 | pmid = 18500969 | pmc = 2129166 | doi = 10.1186/1550-2783-3-2-19 | doi-access = free }}</ref> However, a 2019 study found significantly higher increases in [[muscle mass]] and [[1RM|one-repetition]] [[bench press]] performance in participants dosed with ecdysterone. The study, funded by the [[World Anti-Doping Agency]], demonstrated a significant [[dose response |dose-responsive]] anabolic effect.<ref>{{cite journal | vauthors = Isenmann E, Ambrosio G, Joseph JF, Mazzarino M, de la Torre X, Zimmer P, Kazlauskas R, Goebel C, Botrè F, Diel P, Parr MK | s2cid = 163166547 | title = Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humans | journal = Archives of Toxicology | volume = 93 | issue = 7 | pages = 1807–1816 | date = July 2019 | pmid = 31123801 | doi = 10.1007/s00204-019-02490-x | bibcode = 2019ArTox..93.1807I | hdl-access = free | hdl = 11573/1291269 }}</ref> Other studies have elucidated the mechanism of action of 20-hydroxyecdysone on human [[muscle cell]]s, which appears to involve relatively selective activation of [[estrogen receptor beta]] (ERβ), known to result in [[muscle hypertrophy]].<ref name="pmid24974955">{{cite journal | vauthors = Parr MK, Zhao P, Haupt O, Ngueu ST, Hengevoss J, Fritzemeier KH, Piechotta M, Schlörer N, Muhn P, Zheng WY, Xie MY, Diel P | title = Estrogen receptor beta is involved in skeletal muscle hypertrophy induced by the phytoecdysteroid ecdysterone | journal = Molecular Nutrition & Food Research | volume = 58 | issue = 9 | pages = 1861–72 | date = September 2014 | pmid = 24974955 | doi = 10.1002/mnfr.201300806 }}</ref> It has recently been identified as a [[Mas receptor]] agonist as well.