Editing Absence seizure (section)

==Pathophysiology==
The corticothalamic cortical circuit plays an important role in the pathophysiology of absence seizure. Some of the neurons are important in their occurrence. They are
* Cortical glutamatergic neurons
* Thalamic relay neurons
* Neurons of thalamic nucleus reticularis
Abnormal oscillatory rhythms develop in the thalamic nucleus reticularis. This causes inhibition of GABAergic neurotransmission and excitation of glutamate neurotransmission. Abnormal oscillatory spikes are produced by the low threshold T-type calcium channel. This explains how inheritance of gene code for T-type calcium channel leads to an absence seizure. Antiepileptic drugs such as [[Gabapentin]], [[Tiagabine]] and [[Vigabatrin]] cause inhibition of GABA resulting in exacerbation of absence seizures.<ref name=medscape/><ref name="Albuja 2021"/>