Editing Bacteriocin (section)

====Colicin-like bacteriocins====
[[Colicins]] are bacteriocins found in the Gram-negative ''E. coli''. Similar bacteriocins (CLBs, colicin-like bacteriocins) occur in other Gram-negative bacteria. CLBs typically target same species and have species-specific names: klebicins from ''Klebsiella'' and pesticins from ''Yersinia pestis''.<ref>{{cite journal | vauthors = Behrens HM, Six A, Walker D, Kleanthous C | title = The therapeutic potential of bacteriocins as protein antibiotics | journal = Emerging Topics in Life Sciences | volume = 1 | issue = 1 | pages = 65–74 | date = April 2017 | pmid = 33525816 | pmc = 7243282 | doi = 10.1042/ETLS20160016 | veditors = Walker D }}</ref> ''Pseudomonas'' -genus produces bacteriocins called [[pyocin]]s. S-type pyocins belong to CLBs, but R- and F-type pyocins belong to tailocins.<ref>{{cite journal | vauthors = Michel-Briand Y, Baysse C | title = The pyocins of Pseudomonas aeruginosa | journal = Biochimie | volume = 84 | issue = 5–6 | pages = 499–510 | date = May 2002 | pmid = 12423794 | doi = 10.1016/S0300-9084(02)01422-0 }}</ref>

CLBs are distinct from Gram-positive bacteriocins. They are modular proteins between 20 and 90 kDa in size. They often consist of a receptor binding domain, a translocation domain and a cytotoxic domain. Combinations of these domains between different CLBs occur frequently in nature and can be created in the laboratory. Due to these combinations further subclassification can be based on either import mechanism (group A and B) or on cytotoxic mechanism (nucleases, pore forming, M-type, L-type).<ref name="Colicin biology" />