Editing C-reactive protein (section)

===Measurement methods===
Traditional CRP measurement only detected CRP in the range of 10&nbsp;to&nbsp;1,000&nbsp;mg/L, whereas high sensitivity CRP (hs-CRP) detects CRP in the range of 0.5&nbsp;to&nbsp;10&nbsp;mg/L.<ref name="USPharmacist">{{cite web | vauthors = Knight ML | title = The Application of High-Sensitivity C-Reactive Protein in Clinical Practice: A 2015 Update | work = Cardiovascular | publisher = [[U.S. Pharmacist]] | date = February 18, 2015 | url = https://www.uspharmacist.com/article/the-application-of-high-sensitivity-creactive-protein-in-clinical-practice#:~:text=Defining%20hs-CRP,of%20CRP%20in%20the%20blood  | access-date = 2020-12-28 }}</ref> hs-CRP can detect [[cardiovascular disease]] risk when in excess of 3&nbsp;mg/L, whereas below 1&nbsp;mg/L would be low risk.<ref name="pmid12551878">{{cite journal | vauthors = Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL, Rifai N, Smith SC, Taubert K, Tracy RP, Vinicor F | title = Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association | journal = Circulation | volume = 107 | issue = 3 | pages = 499–511 | date = January 2003 | pmid = 12551878 | doi = 10.1161/01.cir.0000052939.59093.45 | doi-access = free }}</ref> Traditional CRP measurement is faster and less costly than hs-CRP, and can be adequate for some applications, such as monitoring [[hemodialysis]] patients.<ref name="pmid22569431">{{cite journal | vauthors = Helal I, Zerelli L, Krid M, ElYounsi F, Ben Maiz H, Zouari B, Adelmoula J, Kheder A | title = Comparison of C-reactive protein and high-sensitivity C-reactive protein levels in patients on hemodialysis | journal = Saudi Journal of Kidney Diseases and Transplantation | volume = 23 | issue = 3 | pages = 477–483 | date = May 2012 | pmid = 22569431 | url = https://www.sjkdt.org/temp/SaudiJKidneyDisTranspl233477-6599427_181954.pdf | access-date = 2020-12-28 | url-status = dead | archive-url = https://web.archive.org/web/20211209104151/https://www.sjkdt.org/temp/SaudiJKidneyDisTranspl233477-6599427_181954.pdf | archive-date = 2021-12-09 }}</ref> Current immunoassay methods for CRP have similar precision to hsCRP performed by nephelometry and could probably replace hsCRP for cardiovascular risk assessment,<ref>{{cite journal | vauthors = Han E, Fritzer-Szekeres M, Szekeres T, Gehrig T, Gyöngyösi M, Bergler-Klein J | title = Comparison of High-Sensitivity C-Reactive Protein vs C-reactive Protein for Cardiovascular Risk Prediction in Chronic Cardiac Disease | journal = The Journal of Applied Laboratory Medicine | volume = 7 | issue = 6 | pages = 1259–1271 | date = October 2022 | pmid = 36136302 | doi = 10.1093/jalm/jfac069 }}</ref> however, in the United States this would represent off-label use, making it a laboratory-developed test under FDA regulations.<ref>{{cite journal | vauthors = Wolska A, Remaley AT | title = CRP and High-Sensitivity CRP: "What's in a Name?" | journal = The Journal of Applied Laboratory Medicine | volume = 7 | issue = 6 | pages = 1255–1258 | date = October 2022 | pmid = 36136105 | doi = 10.1093/jalm/jfac076 | doi-access = free }}</ref>