Editing Chemoreceptor trigger zone (section)

===H-channels===

Most of the neurons located in the CTZ express hyperpolarization-activated cation channels (H-channels).<ref name="Shinpo">{{cite journal|last1=Shinpo|first1=K|last2=Hirai|first2=Y|last3=Maezawa|first3=H|last4=Totsuka|first4=Y|last5=Funahashi|first5=M|title=The role of area postrema neurons expressing H-channels in the induction mechanism of nausea and vomiting|journal=Physiology & Behavior|date=20 August 2012|volume=107|issue=1|pages=98–103|doi=10.1016/j.physbeh.2012.06.002|pmid=22722099|s2cid=23070726}}</ref> Since the neurons in the CTZ convey information relating to emesis to the other parts of the vomiting center, it was thought that these H-channels might play a role in nausea and the emetic response. Recently, evidence of this notion that H-channels in CTZ neurons play a role in emesis has come to light. It has been found that ZD7288, which is a H-channel inhibitor, inhibited the acquisition of [[conditioned taste aversion]] (CTA) in rats and reduced [[apomorphine]]-induced [[c-Fos]] expression in the area postrema where the CTZ is located.<ref name="Shinpo"/> This suggests that the neurons that express H-channels in the CTZ and area postrema are involved in nausea and the emetic response.<ref name="Shinpo"/>