Editing Cisplatin (section)

===Transplatin===
[[Trans-Dichlorodiammineplatinum(II)|Transplatin]], the [[Cis–trans isomerism#Coordination complexes|''trans''-stereoisomer]] of cisplatin, has formula [[trans-Dichlorodiammineplatinum(II)|''trans''-[PtCl<sub>2</sub>(NH<sub>3</sub>)<sub>2</sub>]]] and does not exhibit a comparably useful pharmacological effect. Two mechanisms have been suggested to explain the reduced anticancer effect of transplatin. Firstly, the ''trans'' arrangement of the chloro ligands is thought to confer transplatin with greater chemical reactivity, causing transplatin to become deactivated before it reaches the DNA, where cisplatin exerts its pharmacological action. Secondly, the stereo-conformation of transplatin is such that it is unable to form the characteristic 1,2-intrastrand d(GpG) adducts formed by cisplatin in abundance.<ref>{{cite journal | vauthors = Coluccia M, Natile G | title = Trans-platinum complexes in cancer therapy | journal = Anti-Cancer Agents in Medicinal Chemistry | volume = 7 | issue = 1 | pages = 111–123 | date = January 2007 | pmid = 17266508 | doi = 10.2174/187152007779314080 }}</ref>