Editing Clindamycin (section)

=== Malaria ===
Given with [[chloroquine]] or [[quinine]], clindamycin is effective and well tolerated in treating ''[[Plasmodium falciparum]]'' malaria; the latter combination is particularly useful for children, and is the treatment of choice for pregnant women who become infected in areas where [[drug resistance|resistance]] to chloroquine is common.<ref name=Lell2002>{{cite journal |vauthors=Lell B, Kremsner PG |title=Clindamycin as an antimalarial drug: review of clinical trials |journal=[[Antimicrobial Agents and Chemotherapy]] |issn=0066-4804 |volume=46 |issue=8 |pages=2315–20 |year=2002 |pmid=12121898 |doi=10.1128/AAC.46.8.2315-2320.2002 |pmc=127356 | doi-access=free | title-link=doi }}</ref><ref name="Griffith">{{cite journal |vauthors=Griffith KS, Lewis LS, Mali S, Parise ME |title=Treatment of malaria in the United States: a systematic review |journal=JAMA |volume=297 |issue=20 |pages=2264–77 |year=2007 |pmid=17519416 |doi=10.1001/jama.297.20.2264 |doi-access=free | title-link=doi }}</ref> Clindamycin should not be used as an antimalarial by itself, although it appears to be very effective as such, because of its slow action.<ref name=Lell2002 /><ref name="Griffith" /> Patient-derived isolates of ''[[Plasmodium falciparum]]'' from the [[Peruvian Amazonia|Peruvian Amazon]] have been reported to be resistant to clindamycin as evidenced by ''in vitro'' drug susceptibility testing.<ref name="Dharia">{{cite journal |vauthors=Dharia NV, Plouffe D, Bopp SE, González-Páez GE, Lucas C, Salas C, Soberon V, Bursulaya B, Kochel TJ, Bacon DJ, Winzeler EA |title=Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites |journal=[[Genome Research]] |volume=20 |issue=11 |pages=1534–44 |year=2010 |pmid=20829224 |doi=10.1101/gr.105163.110 |pmc=2963817 }}</ref>