Editing Clonal anergy (section)

==Testing==
The "Multitest Mérieux" or "CMI Multitest" system (Multitest IMC, Istituto Merieux Italia, Rome, Italy) has been used as a general test of the level of [[cellular immunity]]. It is an [[intradermal]] test of [[skin reactivity]] (similar to [[tuberculin test]]s) in which a control ([[glycerol]]) is used with seven antigens of bacterial or fungal origin ([[tetanus toxoid]], [[tuberculin]], [[diphtheria]], [[streptococcus]], [[Candida (genus)|candida]], [[trichophyton]], and [[Proteus (bacterium)|proteus]]). In this test reactions are categorized according to the number of antigens provoking a response and the summed extent of the skin response to all seven antigens. Here '''anergy''' is defined as a region of skin reactivity of 0–1&nbsp;mm, '''hypoergy''' as a reaction of 2–9&nbsp;mm in response to fewer than three antigens, '''normergic''' as a reaction of 10–39&nbsp;mm or to three or more antigens, and '''hyperergy''' for a reaction of 40&nbsp;mm or more.<ref name="Muller et al">{{cite journal | vauthors = Müller N, Schneider T, Zeitz M, Marth T |year=2001 |title=Whipple's disease: new aspects in pathogenesis and diagnoses |url=http://documents.irevues.inist.fr/bitstream/2042/7452/1/actaend_2001_3_243-253.pdf |journal=Acta Endoscopica |volume=31 |pages=243–253 |doi=10.1007/BF03020891 |s2cid=30195122 }}</ref><ref name="Spornraft et al">{{cite journal | vauthors = Spornraft P, Fröschl M, Ring J, Meurer M, Goebel FD, Ziegler-Heitbrock HW, Riethmüller G, Braun-Falco O | display-authors = 6 | title = T4/T8 ratio and absolute T4 cell numbers in different clinical stages of Kaposi's sarcoma in AIDS | journal = The British Journal of Dermatology | volume = 119 | issue = 1 | pages = 1–9 | date = July 1988 | pmid = 3261596 | doi = 10.1111/j.1365-2133.1988.tb07095.x | url = http://www.rethinkingaids.com/portals/0/TheCD/S/spo.pdf | url-status = dead | s2cid = 29214452 | archive-url = https://web.archive.org/web/20110611232418/http://www.rethinkingaids.com/portals/0/TheCD/S/spo.pdf | archive-date = 2011-06-11 }}</ref><ref name="De Flora et al">{{cite journal | vauthors = De Flora S, Grassi C, Carati L | title = Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment | journal = The European Respiratory Journal | volume = 10 | issue = 7 | pages = 1535–1541 | date = July 1997 | pmid = 9230243 | doi = 10.1183/09031936.97.10071535 | doi-access = free }}</ref>