Editing Corticotropic cell (section)

=== Inhibition of ACTH production ===
Corticotropes contain [[glucocorticoid receptors]] (GRs) and [[Transcortin|corticosteroid-binding globulin]] (CBG, or transcortin). GR is a [[nuclear receptor]] that inhibits transcription of ACTH via a negative glucocorticoid recognition element (GRE) that binds cortisol on POMC [[DNA]], but generally transcortin binds glucocorticoids (including cortisol, cortisone, deoxycortisone, and aldosterone) with high affinity and prevents this inhibition.<ref>{{Cite book|title=Molecular and cellular endocrinology|last1=Bittar|first1=Edward|last2=Bittar|first2=Neville| name-list-style = vanc |date=1997|publisher=JAI Press|isbn=9781559388153|location=Greenwich, Conn.|oclc=162130720}}</ref> Tonic inhibition of corticotropes requires high concentrations of glucocorticoids, exceeding CBG capacity. This causes ACTH secretion to be vulnerable to inhibition in patients taking glucocorticoids for medical purposes such as treatment of autoimmune disease or as an anti-transplant-rejection medication.<ref>{{cite book | vauthors = Pecoraro N, Dallman MF  |chapter=Hypothalamic–Pituitary–Adrenal (HPA) Axis|date=2009 |pages=65–74|publisher=Elsevier | doi=10.1016/b978-008045046-9.00474-5|isbn=9780080450469 |title=Encyclopedia of Neuroscience}}</ref>