Editing Domperidone (section)

===Other uses===

====Parkinson's disease====
[[Parkinson's disease]] is a [[neurodegenerative disease|degenerative neurological condition]] where a decrease in [[dopamine]] in the [[brain]] leads to [[muscle rigidity|rigidity]] (stiffness of movement), [[tremor]], and other symptoms and signs. Poor [[gastrointestinal]] function, [[nausea]], and [[vomiting]] are major problems for people with Parkinson's disease because most medications used to treat Parkinson's disease are given [[oral administration|by mouth]]. These [[medication]]s, such as [[levodopa]], can also cause nausea as a [[side effect]]. Furthermore, [[antiemetic|anti-nausea drugs]], such as [[metoclopramide]], which do cross the [[blood–brain barrier]], may worsen the [[extrapyramidal symptom]]s of Parkinson's disease. Domperidone can be used to relieve nausea and gastrointestinal symptoms in Parkinson's disease; it blocks peripheral D<sub>2</sub> receptors but minimally crosses the blood-brain barrier in normal doses, so has no effect on the extrapyramidal symptoms of the disease.<ref name="pmid30361854">{{cite journal | vauthors = Ramprasad C, Douglas JY, Moshiree B | title = Parkinson's Disease and Current Treatments for Its Gastrointestinal Neurogastromotility Effects | journal = Current Treatment Options in Gastroenterology | volume = 16 | issue = 4 | pages = 489–510 | date = December 2018 | pmid = 30361854 | doi = 10.1007/s11938-018-0201-3 | s2cid = 53104650 }}</ref><ref name="pmid18281732">{{cite journal | vauthors = Lertxundi U, Peral J, Mora O, Domingo-Echaburu S, Martínez-Bengoechea MJ, García-Moncó JC | title = Antidopaminergic therapy for managing comorbidities in patients with Parkinson's disease | journal = American Journal of Health-System Pharmacy | volume = 65 | issue = 5 | pages = 414–419 | date = March 2008 | pmid = 18281732 | doi = 10.2146/ajhp060624 }}</ref><ref name="pmid9108986">{{cite journal | vauthors = Jost WH | title = Gastrointestinal motility problems in patients with Parkinson's disease. Effects of antiparkinsonian treatment and guidelines for management | journal = Drugs & Aging | volume = 10 | issue = 4 | pages = 249–258 | date = April 1997 | pmid = 9108986 | doi = 10.2165/00002512-199710040-00002 | s2cid = 38114001 }}</ref> In addition, domperidone may be useful in the treatment of [[orthostatic hypotension]] caused by [[dopaminergic]] therapy in people with Parkinson's disease.<ref name="BacchiChimKramer2017">{{cite journal | vauthors = Bacchi S, Chim I, Kramer P, Postuma RB | title = Domperidone for Hypotension in Parkinson's Disease: A Systematic Review | journal = J Parkinsons Dis | volume = 7 | issue = 4 | pages = 603–617 | date = 2017 | pmid = 29103053 | doi = 10.3233/JPD-171209 | url = }}</ref><ref name="LiWuCui2023">{{cite journal | vauthors = Papakonstantinou T, Nikolakopoulou A, Higgins JP, Egger M, Salanti G | title = CINeMA: Software for semiautomated assessment of the confidence in the results of network meta-analysis | journal = Campbell Systematic Reviews | volume = 16 | issue = 1 | pages = e1080 | date = March 2020 | pmc = 10056828 | doi = 10.1002/14651858.CD014883 | pmid = 37131978 }}</ref><ref name="Lang2001">{{cite journal | vauthors = Lang AE | title = Acute orthostatic hypotension when starting dopamine agonist therapy in parkinson disease: the role of domperidone therapy | journal = Arch Neurol | volume = 58 | issue = 5 | pages = 835 | date = May 2001 | pmid = 11346387 | doi = 10.1001/archneur.58.5.835 | doi-broken-date = 11 November 2024 | url = }}</ref><ref name="LuchsingerGrilliVelasco1998">{{cite journal | vauthors = Luchsinger A, Grilli M, Velasco M | title = Metoclopramide and domperidone block the antihypertensive effect of bromocriptine in hypertensive patients | journal = Am J Ther | volume = 5 | issue = 2 | pages = 81–88 | date = March 1998 | pmid = 10099042 | doi = 10.1097/00045391-199803000-00005 | url = }}</ref><ref name="SchofferHendersonOMaley2007">{{cite journal | vauthors = Schoffer KL, Henderson RD, O'Maley K, O'Sullivan JD | title = Nonpharmacological treatment, fludrocortisone, and domperidone for orthostatic hypotension in Parkinson's disease | journal = Mov Disord | volume = 22 | issue = 11 | pages = 1543–1549 | date = August 2007 | pmid = 17557339 | doi = 10.1002/mds.21428 | url = }}</ref>

====Other gastrointestinal uses====
Domperidone may be used in [[functional dyspepsia]] in both adults and children.<ref>{{cite journal | vauthors = Xiao M, Qiu X, Yue D, Cai Y, Mo Q | title = Influence of hippophae rhamnoides on two appetite factors, gastric emptying and metabolic parameters, in children with functional dyspepsia | journal = Hellenic Journal of Nuclear Medicine | volume = 16 | issue = 1 | pages = 38–43 | year = 2013 | pmid = 23529392 | doi = <!-- not 10.1967/s002449910070 --> | url=https://www.nuclmed.gr/wp/wp-content/uploads/2017/03/42-4.pdf }}</ref><ref>{{cite journal | vauthors = Huang X, Lv B, Zhang S, Fan YH, Meng LN | title = Itopride therapy for functional dyspepsia: a meta-analysis | journal = World Journal of Gastroenterology | volume = 18 | issue = 48 | pages = 7371–7377 | date = December 2012 | pmid = 23326147 | pmc = 3544044 | doi = 10.3748/wjg.v18.i48.7371 | doi-access = free }}</ref> It has also been found effective in the treatment of [[gastroesophageal reflux disease|reflux]] in children.<ref>{{cite book| vauthors = Kapoor AK, Raju SM |year=2013|title=Illustrated Medical Pharmacology|chapter=7.2 Gastrointestinal Drugs|chapter-url=https://books.google.com/books?id=Le28AQAAQBAJ&pg=PA677|publisher=JP Medical Ltd|page=677|isbn=978-9350906552|access-date=31 October 2014}} (Google Books)</ref> However some specialists consider its risks prohibitory of the treatment of infantile reflux.<ref>{{Cite news|url=https://www.telegraph.co.uk/health/healthnews/11005559/Fear-that-reflux-treatment-for-babies-will-be-denied-under-new-Nice-guidance.html |title=Fear that reflux treatment for babies will be denied under new Nice guidance | vauthors = Smith R |date=1 August 2014 |publisher=[[The Daily Telegraph]] |access-date=31 October 2014 |archive-url=https://web.archive.org/web/20141005121124/http://www.telegraph.co.uk/health/healthnews/11005559/Fear-that-reflux-treatment-for-babies-will-be-denied-under-new-Nice-guidance.html |archive-date=5 October 2014 |url-status=dead  }}</ref>