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Endochondral ossification
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==Fracture healing== For complete recovery of a [[bone fracture|fractured]] bone’s biomechanical functionality, the [[bone healing]] process needs to culminate in the formation of lamellar bone at the fracture site to withstand the same forces and stresses it did before the fracture. [[Bone healing#Secondary healing|Indirect fracture healing]], the most common type of bone repair,<ref name="Richard">{{cite journal|last1=Richard|first1=Marsell|last2=Thomas A|first2=Einhorn|title=The biology of fracture healing|journal=Injury|date=1 June 2012|volume=42|issue=6|pages=551–555|doi=10.1016/j.injury.2011.03.031|pmid=21489527|pmc=3105171}}</ref> relies heavily on endochondral ossification. In this type of healing, endochondral ossification occurs within the fracture gap and external to the periosteum. In contrast, intramembranous ossification takes place directly beneath the periosteum, adjacent to the broken bone’s ends.<ref name="Richard" /><ref>{{cite journal |last1=Bahney |first1=Chelsea S. |last2=Hu |first2=Diane P. |last3=Miclau |first3=Theodore |last4=Marcucio |first4=Ralph S. |title=The Multifaceted Role of the Vasculature in Endochondral Fracture Repair |journal=Frontiers in Endocrinology |date=5 February 2015 |volume=6 |pages=4 |doi=10.3389/fendo.2015.00004 |pmid=25699016 |issn=1664-2392 |pmc=4318416|doi-access=free}}</ref> [[File:Endo Fracture.jpg|upright=1.5|thumb|A schematic of endochondral fracture, where '''B''' shows the location of both endochondral and intramembranous ossification.]]
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