Editing Ergoline (section)

=== Dopaminergic/antidopaminergic ===
Ergolines, such as ergotoxin, have been reported to inhibit the deciduoma reaction, which is reversed through injection of progesterone. Thus, it was concluded that ergotoxin, and related ergolines, act via the [[hypothalamus]] and [[pituitary gland]] to inhibit the [[secretion]] of [[prolactin]].<ref name=":4" /> Drugs such as [[bromocriptine]] interact with the dopaminergic receptor sites as agonists with selectivity for D<sub>2</sub> receptors, making them effective in treating Parkinson's disease. While the part of the ergoline alkaloid structure responsible for dopaminergic properties has yet to be identified, some reason that it is due to the pyroleethylamine moiety while others assert that it is due to the indoleethylamine partial structure.<ref name=":4" />

Antidopaminergic ergolines have found use in [[antiemetic]]s and in the treatment of [[schizophrenia]]. These substances are [[neuroleptic]] and are either an antagonist of dopamine at the postsynaptic level at the D<sub>2</sub> receptor site or an agonist of dopamine at the presynaptic level at the D<sub>1</sub> receptor site.<ref name=":4" /> The antagonist or agonist behavior of the ergolines are substrate dependent and mixed agonist/antagonist behaviors of ergoline derivatives have been reported.<ref name=":4" />