Editing Folate (section)

===Heart disease===
One meta-analysis reported that multi-year folic acid supplementation, in amounts in most of the included clinical trials at higher than the upper limit of 1,000&nbsp;μg/day, reduced the [[relative risk]] of cardiovascular disease by a modest 4%.<ref name=Li2016/> Two older meta-analyses, which would not have incorporated results from newer clinical trials, reported no changes to the risk of cardiovascular disease.<ref>{{cite journal |vauthors=Yang HT, Lee M, Hong KS, Ovbiagele B, Saver JL |title=Efficacy of folic acid supplementation in cardiovascular disease prevention: an updated meta-analysis of randomized controlled trials |journal=Eur. J. Intern. Med. |volume=23 |issue=8 |pages=745–54 |date=December 2012 |pmid=22884409 |doi=10.1016/j.ejim.2012.07.004 }}</ref><ref>{{cite journal|vauthors=Bazzano LA|s2cid=20470125|title=No effect of folic acid supplementation on cardiovascular events, cancer or mortality after 5 years in people at increased cardiovascular risk, although homocysteine levels are reduced|journal=Evidence-Based Medicine|volume=16|issue=4|pages=117–8|date=August 2011|pmid=21402567|doi=10.1136/ebm1204}}</ref>