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Free-radical theory of aging
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===Epigenetic oxidative redox shift=== Brewer proposed a theory which integrates the free radical theory of aging with the [[insulin]] signalling effects in aging.<ref name="Brewer GJ 2010 173β9">{{cite journal | author = Brewer GJ | year = 2010 | title = Epigenetic oxidative redox shift (EORS) theory of aging unifies the free radical and insulin signaling theories | journal = Experimental Gerontology | volume = 45 | issue = 3| pages = 173β9 | doi=10.1016/j.exger.2009.11.007| pmid = 19945522 | pmc = 2826600}}</ref> Brewer's theory suggests "sedentary behaviour associated with age triggers an oxidized [[redox]] shift and impaired mitochondrial function".<ref name="Brewer GJ 2010 173β9"/> This mitochondrial impairment leads to more sedentary behaviour and accelerated aging.<ref name="Brewer GJ 2010 173β9"/>
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