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Gabapentin
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===Sleep=== Gabapentin is effective in treating sleep disorders such as insomnia and [[restless legs syndrome]] that are the result of an underlying illness, but comes with some risk of [[Medication discontinuation|discontinuation]] and [[Drug withdrawal|withdrawal symptoms]] after prolonged use at higher doses.<ref name="pmid28769860">{{cite journal | vauthors = Liu GJ, Karim MR, Xu LL, Wang SL, Yang C, Ding L, Wang YF | title = Efficacy and Tolerability of Gabapentin in Adults with Sleep Disturbance in Medical Illness: A Systematic Review and Meta-analysis | journal = Frontiers in Neurology | volume = 8 | pages = 316 | date = 2017 | pmid = 28769860 | pmc = 5510619 | doi = 10.3389/fneur.2017.00316 | title-link = doi | doi-access = free }}</ref> Gabapentin enhances [[slow-wave sleep]] in people with primary insomnia. It also improves sleep quality by elevating sleep efficiency and decreasing spontaneous [[arousal]].<ref name="pmid20124884">{{cite journal | vauthors = Lo HS, Yang CM, Lo HG, Lee CY, Ting H, Tzang BS | title = Treatment effects of gabapentin for primary insomnia | journal = Clinical Neuropharmacology | volume = 33 | issue = 2 | pages = 84β90 | date = 2010 | pmid = 20124884 | doi = 10.1097/WNF.0b013e3181cda242 | s2cid = 4046961 }}</ref>
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