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Hardy–Weinberg principle
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=== Generalization for more than two alleles === [[File:Hardy–Weinberg law - Punnett square2.svg|thumb|Punnett square for three-allele case (left) and four-allele case (right). White areas are homozygotes. Colored areas are heterozygotes.]] Consider an extra allele frequency, ''r''. The two-allele case is the [[binomial theorem|binomial expansion]] of (''p'' + ''q'')<sup>2</sup>, and thus the three-allele case is the trinomial expansion of (''p'' + ''q'' + ''r'')<sup>2</sup>. :<math>(p+q+r)^2=p^2 + q^2 + r^2 + 2pq +2pr + 2qr\,</math> More generally, consider the alleles A<sub>1</sub>, ..., A<sub>''n''</sub> given by the allele frequencies ''p''<sub>1</sub> to ''p''<sub>''n''</sub>; :<math>(p_1 + \cdots + p_n)^2\,</math> giving for all [[Zygosity|homozygotes]]: :<math>f(A_i A_i) = p_i^2\,</math> and for all [[Zygosity|heterozygotes]]: :<math>f(A_i A_j) = 2p_ip_j\,</math>
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