Editing Histidine (section)

==== Regulation of biosynthesis ====
This pathway requires energy in order to occur therefore, the presence of ATP activates the first enzyme of the pathway, ATP-phosphoribosyl transferase (shown as His1 in the image on the right). ATP-phosphoribosyl transferase is the rate determining enzyme, which is regulated through feedback inhibition meaning that it is inhibited in the presence of the product, histidine.<ref>{{Cite journal|last1=Cheng|first1=Yongsong|last2=Zhou|first2=Yunjiao|last3=Yang|first3=Lei|last4=Zhang|first4=Chenglin|last5=Xu|first5=Qingyang|last6=Xie|first6=Xixian|last7=Chen|first7=Ning|date=2013-05-01|title=Modification of histidine biosynthesis pathway genes and the impact on production of L-histidine in ''Corynebacterium glutamicum''|journal=Biotechnology Letters|volume=35|issue=5|pages=735–741|doi=10.1007/s10529-013-1138-1|issn=1573-6776|pmid=23355034|s2cid=18380727}}</ref>