Editing Infliximab (section)

===Ulcerative colitis===
Infliximab targets [[tumour necrosis factor|TNF]], thought to be more related to [[T helper cell#Th1/Th2 Model for helper T cells|Th1]] cytokines. Ulcerative colitis was thought to be a [[T helper cell#Th1/Th2 Model for helper T cells|Th2]] disease, and infliximab would be of limited use. However, patients with ulcerative colitis have begun to be treated with infliximab on the basis of two large clinical trials conducted in 2005 by Paul Rutgeerts and William Sandborn. The Acute ulcerative Colitis Treatment trials (ACT1 and ACT2) to evaluate the utility of infliximab in ulcerative colitis showed 44–45% of patients treated with infliximab for a year maintained a response to the medication, compared with 21% of patients who were treated with placebo medication. At two months, the response was 61–69% for patients treated with infliximab, and 31% for those treated with placebo.<ref name=ACT>{{cite journal | vauthors = Rutgeerts P, Sandborn WJ, Feagan BG, Reinisch W, Olson A, Johanns J, Travers S, Rachmilewitz D, Hanauer SB, Lichtenstein GR, de Villiers WJ, Present D, Sands BE, Colombel JF | title = Infliximab for induction and maintenance therapy for ulcerative colitis | journal = [[The New England Journal of Medicine]] | volume = 353 | issue = 23 | pages = 2462–76 | year = 2005 | pmid = 16339095 | doi = 10.1056/NEJMoa050516 | doi-access = free }}</ref>