Editing Interactome (section)

==Interactomics==
'''Interactomics''' is a discipline at the intersection of [[bioinformatics]] and [[biology]] that deals with studying both the interactions and the consequences of those interactions between and among [[protein]]s, and other molecules within a [[cell (biology)|cell]].<ref name="Klemer">{{cite journal | last =Kiemer | first=L |author2=G Cesareni | year = 2007| title = Comparative interactomics: comparing apples and pears? | journal= Trends in Biotechnology | volume = 25 |pages = 448–454 | doi =10.1016/j.tibtech.2007.08.002 | pmid =17825444 | issue =10}}</ref> Interactomics thus aims to compare such networks of interactions (i.e., interactomes) between and within species in order to find how the traits of such networks are either preserved or varied.

Interactomics is an example of "top-down" [[systems biology]], which takes an overhead view of a biosystem or organism. Large sets of genome-wide and proteomic data are collected, and correlations between different molecules are inferred. From the data new hypotheses are formulated about feedbacks between these molecules. These hypotheses can then be tested by new experiments.<ref name="Bruggeman">{{cite journal | last =Bruggeman | first=F J |author2=H V Westerhoff| year = 2006| title = The nature of systems biology | journal= Trends in Microbiology | volume = 15 |pages = 45–50| doi = 10.1016/j.tim.2006.11.003 |pmid =17113776 | issue =1}}</ref>