Editing Iron overload (section)

==== Hemosiderosis ====
In general, the term ''[[haemosiderosis|hemosiderosis]]'' is used to indicate the pathological effect of iron accumulation in any given organ, which mainly occurs in the form of the iron-storage complex [[haemosiderin|hemosiderin]].<ref>[http://www.merriam-webster.com/medical/hemosideroses Merriam-Webster's Medical Dictionary > hemosideroses] Retrieved on December 11, 2009</ref><ref>[http://medical-dictionary.thefreedictionary.com/hemosiderosis thefreedictionary.com > hemosiderosis], citing:
* ''The American Heritage Medical Dictionary'', 2004 by Houghton Mifflin Company
* ''Mosby's Medical Dictionary'', 8th edition.</ref> Sometimes, the simpler term [[siderosis]] is used instead.

Other definitions distinguishing hemochromatosis or hemosiderosis that are occasionally used include:
* Hemosiderosis is hemochromatosis caused by excessive blood transfusions, that is, hemosiderosis is a form of secondary hemochromatosis.<ref>[http://emedicine.medscape.com/article/369012-overview eMedicine Specialties > Radiology > Gastrointestinal > Hemochromatosis] Author: Sandor Joffe, MD. Updated: May 8, 2009</ref><ref>[http://medical-dictionary.thefreedictionary.com/hemosiderosis thefreedictionary.com > hemosiderosis], citing:
* ''Gale Encyclopedia of Medicine. Copyright 2008''</ref>
* Hemosiderosis is hemosiderin deposition within cells, while hemochromatosis is hemosiderin within cells and interstitium.<ref>[http://chorus.rad.mcw.edu/to-go/00184.html Notecards on radiology gamuts, diseases, anatomy] {{Webarchive|url=https://web.archive.org/web/20100721200303/http://chorus.rad.mcw.edu/to-go/00184.html |date=2010-07-21 }} 2002, Charles E. Kahn, Jr., MD. Medical College of Wisconsin</ref>
* Hemosiderosis is iron overload that does not cause tissue damage,<ref>[http://medical-dictionary.thefreedictionary.com/hemosiderosis thefreedictionary.com > hemosiderosis], citing:
* ''Dorland's Medical Dictionary for Health Consumers'', 2007
* ''Mosby's Dental Dictionary'', 2nd ed.
* ''Saunders Comprehensive Veterinary Dictionary'', 3rd ed. 2007</ref> while hemochromatosis does.<ref>[http://www.healthscout.com/ency/68/743/main.html The HealthScout Network > Health Encyclopedia > Diseases and Conditions > Hemochromatosis] {{Webarchive|url=https://web.archive.org/web/20100209060309/http://www.healthscout.com/ency/68/743/main.html |date=2010-02-09 }} Retrieved on December 11, 2009</ref>
* Hemosiderosis is arbitrarily differentiated from hemochromatosis by the reversible nature of the iron accumulation in the reticuloendothelial system.<ref>[http://medical-dictionary.thefreedictionary.com/hemosiderosis thefreedictionary.com > hemosiderosis], citing:
* ''McGraw-Hill Concise Dictionary of Modern Medicine''. 2002</ref>
The causes of hemochromatosis broken down into two subcategories: ''primary cases'' (hereditary or genetically determined) and less frequent ''secondary cases'' (acquired during life).<ref name="pmid12651879">{{cite journal |last1=Pietrangelo |first1=A |title=Haemochromatosis |journal=Gut |volume=52 |pages=ii23–30 |year=2003 |pmid=12651879 |pmc=1867747 |doi=10.1136/gut.52.suppl_2.ii23 |issue=90002}}</ref> 

People of Northern European descent, including [[Celts|Celtic]] (Irish, Scottish, Welsh, Cornish, Breton etc.), [[English people|English]], and [[Scandinavia]]n origin<ref>[https://www.theatlantic.com/health/archive/2013/01/the-iron-in-our-blood-that-keeps-and-kills-us/266936/?single_page=true The Atlantic: "The Iron in Our Blood That Keeps and Kills Us" by Bradley Wertheim] January 10, 2013</ref> have a particularly high incidence of hemochromatosis type 1, with about 1:8 people being carriers of the principal genetic variant, the C282Y mutation on the [[HFE (gene)|HFE]] gene, and 0.5% of the population having the condition.<ref>{{cite web|title=Hemachromatosis|url=https://www.britannica.com/science/hemochromatosis|website=Encyclopædia Britannica.com|access-date= 17 April 2017}}</ref>